Antibody That Destroys Ghrelin Increases Metabolism and Reduces Refeeding in Mice
A catalytic antibody that degrades ghrelin increased whole-body metabolic rate and reduced refeeding after fasting in mice — a novel immunological approach to ghrelin blockade for obesity treatment.
Quick Facts
What This Study Found
A ghrelin-degrading catalytic antibody (ghrelin-ase) increased metabolic rate and reduced post-fast refeeding in mice, demonstrating an immunological approach to ghrelin neutralization for obesity treatment — antibody-based appetite suppression.
Key Numbers
How They Did This
animal-study study.
Why This Research Matters
Relevant for neuropeptides, weight-loss, peptide-design.
The Bigger Picture
Advances peptide research.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding A ghrelin-degrading catalytic antibody (ghrelin-ase) increased metabolic rate and reduced post-fast refeeding in mice, demonstrating an immunological
- Evidence Grade:
- preliminary evidence.
- Study Age:
- Published in 2008.
- Original Title:
- Catalytic antibody degradation of ghrelin increases whole-body metabolic rate and reduces refeeding in fasting mice.
- Published In:
- Proceedings of the National Academy of Sciences of the United States of America, 105(45), 17487-92 (2008)
- Authors:
- Mayorov, Alexander V, Amara, Neri, Chang, Jason Y, Moss, Jason A, Hixon, Mark S, Ruiz, Diana I, Meijler, Michael M, Zorrilla, Eric P, Janda, Kim D
- Database ID:
- RPEP-01384
Evidence Hierarchy
Tests effects in animals (usually mice or rats), not humans.
What do these levels mean? →Frequently Asked Questions
What was studied?
Antibody That Destroys Ghrelin Increases Metabolism and Reduces Refeeding in Mice
What was found?
A catalytic antibody that degrades ghrelin increased whole-body metabolic rate and reduced refeeding after fasting in mice — a novel immunological approach to ghrelin blockade for obesity treatment.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-01384APA
Mayorov, Alexander V; Amara, Neri; Chang, Jason Y; Moss, Jason A; Hixon, Mark S; Ruiz, Diana I; Meijler, Michael M; Zorrilla, Eric P; Janda, Kim D. (2008). Catalytic antibody degradation of ghrelin increases whole-body metabolic rate and reduces refeeding in fasting mice.. Proceedings of the National Academy of Sciences of the United States of America, 105(45), 17487-92. https://doi.org/10.1073/pnas.0711808105
MLA
Mayorov, Alexander V, et al. "Catalytic antibody degradation of ghrelin increases whole-body metabolic rate and reduces refeeding in fasting mice.." Proceedings of the National Academy of Sciences of the United States of America, 2008. https://doi.org/10.1073/pnas.0711808105
RethinkPeptides
RethinkPeptides Research Database. "Catalytic antibody degradation of ghrelin increases whole-bo..." RPEP-01384. Retrieved from https://rethinkpeptides.com/research/mayorov-2008-catalytic-antibody-degradation-of
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.