A catalytic antibody that degrades ghrelin increased whole-body metabolic rate and reduced refeeding after fasting in mice — a novel immunological approach to ghrelin blockade for obesity treatment.
Key findingA ghrelin-degrading catalytic antibody (ghrelin-ase) increased metabolic rate and reduced post-fast refeeding in mice, demonstrating an immunological
What the researchers found
A ghrelin-degrading catalytic antibody (ghrelin-ase) increased metabolic rate and reduced post-fast refeeding in mice, demonstrating an immunological approach to ghrelin neutralization for obesity treatment — antibody-based appetite suppression.
Why it matters
Relevant for neuropeptides, weight-loss, peptide-design.
How the study worked
animal-study study.
What this study cannot tell us
See abstract.
How to read the evidence
preliminary evidence.
When this study was published
Published in 2008.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Catalytic antibody degradation of ghrelin increases whole-body metabolic rate and reduces refeeding in fasting mice.
Proceedings of the National Academy of Sciences of the United States of America, 105(45), 17487-92
Citation
Mayorov, Alexander V; Amara, Neri; Chang, Jason Y; Moss, Jason A; Hixon, Mark S; Ruiz, Diana I; Meijler, Michael M; Zorrilla, Eric P; Janda, Kim D. (2008). Catalytic antibody degradation of ghrelin increases whole-body metabolic rate and reduces refeeding in fasting mice.. Proceedings of the National Academy of Sciences of the United States of America, 105(45), 17487-92. https://doi.org/10.1073/pnas.0711808105