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Study breakdown

Neuropeptides in Wound Vacuum Therapy: Substance P and CGRP in Tissue Trauma Response

evidence
The takeaway

Negative pressure wound therapy with foam vs gauze produced different tissue trauma and neuropeptide (substance P, CGRP) responses, revealing the neural peptide component of wound therapy-induced pain and healing.

Key finding

Negative pressure wound therapy with foam vs gauze produced different tissue trauma and neuropeptide (substance P, CGRP) responses, revealing the neur

What the researchers found

Negative pressure wound therapy with foam vs gauze produced different tissue trauma and neuropeptide (substance P, CGRP) responses, revealing the neural peptide component of wound therapy-induced pain and healing.

Why it matters

Relevant for peptide research.

How the study worked

research study.

What this study cannot tell us

See abstract.

How to read the evidence

emerging evidence.

When this study was published

Published in 2011.

The bigger picture

Advances peptide research.

Questions still open

  • Further research needed.

Common questions

What was studied?
Neuropeptides in Wound Vacuum Therapy: Substance P and CGRP in Tissue Trauma Response
What was found?
Negative pressure wound therapy with foam vs gauze produced different tissue trauma and neuropeptide (substance P, CGRP) responses, revealing the neural peptide component of wound therapy-induced pain and healing.

Read the original research

Negative pressure wound therapy-associated tissue trauma and pain: a controlled in vivo study comparing foam and gauze dressing removal by immunohistochemistry for substance P and calcitonin gene-related peptide in the wound edge.

Ostomy/wound management, 57(12), 30-5

Citation

Malmsjö, Malin; Gustafsson, Lotta; Lindstedt, Sandra; Ingemansson, Richard. (2011). Negative pressure wound therapy-associated tissue trauma and pain: a controlled in vivo study comparing foam and gauze dressing removal by immunohistochemistry for substance P and calcitonin gene-related peptide in the wound edge.. Ostomy/wound management, 57(12), 30-5.