Bovine lactoferricin selectively induced apoptosis in leukemia and carcinoma cell lines while sparing normal lymphocytes and fibroblasts — demonstrating true cancer selectivity with clinical potential.
Key findingBovine lactoferricin induced apoptosis selectively in human leukemia (Jurkat, CEM) and carcinoma (MDA-MB-435) cell lines while sparing normal lymphocy
What the researchers found
Bovine lactoferricin induced apoptosis selectively in human leukemia (Jurkat, CEM) and carcinoma (MDA-MB-435) cell lines while sparing normal lymphocytes and fibroblasts — demonstrating cancer-selective cytotoxicity through membrane-dependent mechanisms.
Why it matters
Relevant for antimicrobial-peptides, cancer.
How the study worked
in-vitro study on antimicrobial-peptides, cancer.
What this study cannot tell us
See abstract.
How to read the evidence
preliminary evidence.
When this study was published
Published in 2005.
The bigger picture
Advances peptide research with clinical implications.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Bovine lactoferricin selectively induces apoptosis in human leukemia and carcinoma cell lines.
Molecular cancer therapeutics, 4(4), 612-24
Citation
Mader, Jamie S; Salsman, Jayme; Conrad, David M; Hoskin, David W. (2005). Bovine lactoferricin selectively induces apoptosis in human leukemia and carcinoma cell lines.. Molecular cancer therapeutics, 4(4), 612-24.