Lactoferricin Selectively Kills Cancer Cells While Sparing Normal Cells

Bovine lactoferricin selectively induced apoptosis in leukemia and carcinoma cell lines while sparing normal lymphocytes and fibroblasts — demonstrating true cancer selectivity with clinical potential.

Mader, Jamie S et al.·Molecular cancer therapeutics·2005·Preliminary Evidencein-vitro
RPEP-01067In VitroPreliminary Evidence2005RETHINKTHC RESEARCH DATABASErethinkthc.com/research

Quick Facts

Study Type
in-vitro
Evidence
Preliminary Evidence
Sample
Not reported

What This Study Found

Bovine lactoferricin induced apoptosis selectively in human leukemia (Jurkat, CEM) and carcinoma (MDA-MB-435) cell lines while sparing normal lymphocytes and fibroblasts — demonstrating cancer-selective cytotoxicity through membrane-dependent mechanisms.

Key Numbers

How They Did This

in-vitro study on antimicrobial-peptides, cancer.

Why This Research Matters

Relevant for antimicrobial-peptides, cancer.

The Bigger Picture

Advances peptide research with clinical implications.

What This Study Doesn't Tell Us

See abstract.

Questions This Raises

  • ?Further research needed.
  • ?Clinical translation to evaluate.

Trust & Context

Key Stat:
Key finding Bovine lactoferricin induced apoptosis selectively in human leukemia (Jurkat, CEM) and carcinoma (MDA-MB-435) cell lines while sparing normal lymphocy
Evidence Grade:
preliminary evidence.
Study Age:
Published in 2005.
Original Title:
Bovine lactoferricin selectively induces apoptosis in human leukemia and carcinoma cell lines.
Published In:
Molecular cancer therapeutics, 4(4), 612-24 (2005)
Database ID:
RPEP-01067

Evidence Hierarchy

Meta-Analysis / Systematic Review
Randomized Controlled Trial
Cohort / Case-Control
Cross-Sectional / ObservationalSnapshot without intervening
This study
Case Report / Animal Study
What do these levels mean? →

Frequently Asked Questions

What was studied?

Lactoferricin Selectively Kills Cancer Cells While Sparing Normal Cells

What was found?

Bovine lactoferricin selectively induced apoptosis in leukemia and carcinoma cell lines while sparing normal lymphocytes and fibroblasts — demonstrating true cancer selectivity with clinical potential.

Read More on RethinkPeptides

Cite This Study

RPEP-01067·https://rethinkpeptides.com/research/RPEP-01067

APA

Mader, Jamie S; Salsman, Jayme; Conrad, David M; Hoskin, David W. (2005). Bovine lactoferricin selectively induces apoptosis in human leukemia and carcinoma cell lines.. Molecular cancer therapeutics, 4(4), 612-24.

MLA

Mader, Jamie S, et al. "Bovine lactoferricin selectively induces apoptosis in human leukemia and carcinoma cell lines.." Molecular cancer therapeutics, 2005.

RethinkPeptides

RethinkPeptides Research Database. "Bovine lactoferricin selectively induces apoptosis in human ..." RPEP-01067. Retrieved from https://rethinkpeptides.com/research/mader-2005-bovine-lactoferricin-selectively-induces

Access the Original Study

Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.

This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.