Sacubitril/Valsartan vs Enalapril in Heart Failure Due to Chagas Disease: An Open-Label, Multicenter Randomized Clinical Trial.

Lopes, Renato D et al.·JAMA·2026·
RPEP-156012026RETHINKTHC RESEARCH DATABASErethinkthc.com/research

Quick Facts

Study Type
Not classified
Evidence
Not graded
Sample
Not reported

What This Study Found

Key Numbers

How They Did This

Why This Research Matters

What This Study Doesn't Tell Us

Trust & Context

Original Title:
Sacubitril/Valsartan vs Enalapril in Heart Failure Due to Chagas Disease: An Open-Label, Multicenter Randomized Clinical Trial.
Published In:
JAMA, 335(1), 49-59 (2026)
Authors:
Lopes, Renato D, Bocchi, Edimar Alcides, Echeverría, Luis Eduardo, Demacq, Caroline, de Barros E Silva, Pedro Gabriel Melo, Barbosa, Lilian Mazza, Damiani, Lucas, Sayyed, Sarfaraz, Yoshida, Liandra A F, Furtado, Remo Holanda M, Morillo, Carlos A, Kevorkian, Ruben, Ramires, Felix, Bahit, M Cecilia, Magaña, Antonio, Chávez-Mendoza, Adolfo, Miguel da Silva, Adegil Henrique, Coelho da Silva, Aguinaldo, Freitas, Aguinaldo F, Romano, Alfredo Alejandro, Parneix, Anne, Segura, Armando, França, Cesar Cassio Broilo, Botta, Cristian Edgardo, de Barros, Edileide, Perna, Eduardo Roque, Montenegro, Eleonora, Quiroz Diaz, Franklin Roberto, Feitosa-Filho, Gilson Soares, Severini, Graciela Viviana, Molina, Israel, Miranda, Jacqueline Dos Santos Sampaio, Sala, Jorgelina, Kerr Saraiva, José Francisco, Carbajales, Justo, Maia, Lilia Nigro, Santana Passos, Luiz Carlos, Simões, Marcus Vinicius, Moreira, Maria da Consolação V, Nunes, Maria Carmo P, Hernandes, Mauro Esteves, Hominal, Miguel, Zarandon, Raquel Saa, Leon de la Fuente, Ricardo, Aras, Roque, Bazan, Silméia Garcia Zanati, Luiz da Silva, Telêmaco, Madrini, Vagner, de Oliveira, Wilson Alves, Saporito, Wladmir Faustino, Gimpelewicz, Claudio, McMurray, John J V
Database ID:
RPEP-15601

Evidence Hierarchy

Meta-Analysis / Systematic Review
Randomized Controlled Trial
Cohort / Case-Control
Cross-Sectional / ObservationalSnapshot without intervening
This study
Case Report / Animal Study
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RPEP-15601·https://rethinkpeptides.com/research/RPEP-15601

APA

Lopes, Renato D; Bocchi, Edimar Alcides; Echeverría, Luis Eduardo; Demacq, Caroline; de Barros E Silva, Pedro Gabriel Melo; Barbosa, Lilian Mazza; Damiani, Lucas; Sayyed, Sarfaraz; Yoshida, Liandra A F; Furtado, Remo Holanda M; Morillo, Carlos A; Kevorkian, Ruben; Ramires, Felix; Bahit, M Cecilia; Magaña, Antonio; Chávez-Mendoza, Adolfo; Miguel da Silva, Adegil Henrique; Coelho da Silva, Aguinaldo; Freitas, Aguinaldo F; Romano, Alfredo Alejandro; Parneix, Anne; Segura, Armando; França, Cesar Cassio Broilo; Botta, Cristian Edgardo; de Barros, Edileide; Perna, Eduardo Roque; Montenegro, Eleonora; Quiroz Diaz, Franklin Roberto; Feitosa-Filho, Gilson Soares; Severini, Graciela Viviana; Molina, Israel; Miranda, Jacqueline Dos Santos Sampaio; Sala, Jorgelina; Kerr Saraiva, José Francisco; Carbajales, Justo; Maia, Lilia Nigro; Santana Passos, Luiz Carlos; Simões, Marcus Vinicius; Moreira, Maria da Consolação V; Nunes, Maria Carmo P; Hernandes, Mauro Esteves; Hominal, Miguel; Zarandon, Raquel Saa; Leon de la Fuente, Ricardo; Aras, Roque; Bazan, Silméia Garcia Zanati; Luiz da Silva, Telêmaco; Madrini, Vagner; de Oliveira, Wilson Alves; Saporito, Wladmir Faustino; Gimpelewicz, Claudio; McMurray, John J V. (2026). Sacubitril/Valsartan vs Enalapril in Heart Failure Due to Chagas Disease: An Open-Label, Multicenter Randomized Clinical Trial.. JAMA, 335(1), 49-59. https://doi.org/10.1001/jama.2025.19808

MLA

Lopes, Renato D, et al. "Sacubitril/Valsartan vs Enalapril in Heart Failure Due to Chagas Disease: An Open-Label, Multicenter Randomized Clinical Trial.." JAMA, 2026. https://doi.org/10.1001/jama.2025.19808

RethinkPeptides

RethinkPeptides Research Database. "Sacubitril/Valsartan vs Enalapril in Heart Failure Due to Ch..." RPEP-15601. Retrieved from https://rethinkpeptides.com/research/lopes-2026-sacubitrilvalsartan-vs-enalapril-in

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Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.

This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.