Overweight children showed blunted postprandial ghrelin suppression and reduced PYY responses compared to normal weight children, suggesting childhood obesity involves early disruption of gut appetite peptide signaling.
Key findingOverweight children demonstrated blunted meal-related ghrelin suppression and attenuated PYY3-36 response compared to normal weight peers, indicating
What the researchers found
Overweight children demonstrated blunted meal-related ghrelin suppression and attenuated PYY3-36 response compared to normal weight peers, indicating childhood obesity involves early-onset gut peptide satiety signaling disruption.
Why it matters
Relevant for neuropeptides, weight-loss.
How the study worked
cross-sectional study.
What this study cannot tell us
See abstract.
How to read the evidence
moderate evidence.
When this study was published
Published in 2008.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Meal-related changes in ghrelin, peptide YY, and appetite in normal weight and overweight children.
Obesity (Silver Spring, Md.), 16(3), 547-52
Citation
Lomenick, Jefferson P; Clasey, Jody L; Anderson, James W. (2008). Meal-related changes in ghrelin, peptide YY, and appetite in normal weight and overweight children.. Obesity (Silver Spring, Md.), 16(3), 547-52. https://doi.org/10.1038/oby.2007.129