Overweight Children Have Blunted Ghrelin and PYY Responses to Meals Compared to Normal Weight
Overweight children showed blunted postprandial ghrelin suppression and reduced PYY responses compared to normal weight children, suggesting childhood obesity involves early disruption of gut appetite peptide signaling.
Quick Facts
What This Study Found
Overweight children demonstrated blunted meal-related ghrelin suppression and attenuated PYY3-36 response compared to normal weight peers, indicating childhood obesity involves early-onset gut peptide satiety signaling disruption.
Key Numbers
How They Did This
cross-sectional study.
Why This Research Matters
Relevant for neuropeptides, weight-loss.
The Bigger Picture
Advances peptide research.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding Overweight children demonstrated blunted meal-related ghrelin suppression and attenuated PYY3-36 response compared to normal weight peers, indicating
- Evidence Grade:
- moderate evidence.
- Study Age:
- Published in 2008.
- Original Title:
- Meal-related changes in ghrelin, peptide YY, and appetite in normal weight and overweight children.
- Published In:
- Obesity (Silver Spring, Md.), 16(3), 547-52 (2008)
- Authors:
- Lomenick, Jefferson P, Clasey, Jody L(2), Anderson, James W
- Database ID:
- RPEP-01379
Evidence Hierarchy
A snapshot of a population at one point in time.
What do these levels mean? →Frequently Asked Questions
What was studied?
Overweight Children Have Blunted Ghrelin and PYY Responses to Meals Compared to Normal Weight
What was found?
Overweight children showed blunted postprandial ghrelin suppression and reduced PYY responses compared to normal weight children, suggesting childhood obesity involves early disruption of gut appetite peptide signaling.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-01379APA
Lomenick, Jefferson P; Clasey, Jody L; Anderson, James W. (2008). Meal-related changes in ghrelin, peptide YY, and appetite in normal weight and overweight children.. Obesity (Silver Spring, Md.), 16(3), 547-52. https://doi.org/10.1038/oby.2007.129
MLA
Lomenick, Jefferson P, et al. "Meal-related changes in ghrelin, peptide YY, and appetite in normal weight and overweight children.." Obesity (Silver Spring, 2008. https://doi.org/10.1038/oby.2007.129
RethinkPeptides
RethinkPeptides Research Database. "Meal-related changes in ghrelin, peptide YY, and appetite in..." RPEP-01379. Retrieved from https://rethinkpeptides.com/research/lomenick-2008-mealrelated-changes-in-ghrelin
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.