Mice Without CCK Are Resistant to High-Fat Diet Obesity: The Satiety Hormone's Paradoxical Role
CCK knockout mice were resistant to high-fat diet-induced obesity — paradoxically, losing the satiety hormone CCK protected against weight gain, suggesting CCK has complex metabolic roles beyond simple meal termination.
Quick Facts
What This Study Found
CCK knockout mice were resistant to high-fat diet-induced obesity — paradoxically, losing the satiety hormone CCK protected against weight gain, suggesting CCK has complex metabolic roles beyond simple meal termination.
Key Numbers
How They Did This
research study.
Why This Research Matters
Relevant for peptide research.
The Bigger Picture
Advances peptide research.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
Trust & Context
- Key Stat:
- Key finding CCK knockout mice were resistant to high-fat diet-induced obesity — paradoxically, losing the satiety hormone CCK protected against weight gain, sugge
- Evidence Grade:
- emerging evidence.
- Study Age:
- Published in 2010.
- Original Title:
- Cholecystokinin knockout mice are resistant to high-fat diet-induced obesity.
- Published In:
- Gastroenterology, 138(5), 1997-2005 (2010)
- Authors:
- Lo, Chun-Min(2), King, Alexandra, Samuelson, Linda C, Kindel, Tammy Lyn, Rider, Therese, Jandacek, Ronald J, Raybould, Helen E, Woods, Stephen C, Tso, Patrick
- Database ID:
- RPEP-01653
Evidence Hierarchy
Frequently Asked Questions
What was studied?
Mice Without CCK Are Resistant to High-Fat Diet Obesity: The Satiety Hormone's Paradoxical Role
What was found?
CCK knockout mice were resistant to high-fat diet-induced obesity — paradoxically, losing the satiety hormone CCK protected against weight gain, suggesting CCK has complex metabolic roles beyond simple meal termination.
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Cite This Study
https://rethinkpeptides.com/research/RPEP-01653APA
Lo, Chun-Min; King, Alexandra; Samuelson, Linda C; Kindel, Tammy Lyn; Rider, Therese; Jandacek, Ronald J; Raybould, Helen E; Woods, Stephen C; Tso, Patrick. (2010). Cholecystokinin knockout mice are resistant to high-fat diet-induced obesity.. Gastroenterology, 138(5), 1997-2005. https://doi.org/10.1053/j.gastro.2010.01.044
MLA
Lo, Chun-Min, et al. "Cholecystokinin knockout mice are resistant to high-fat diet-induced obesity.." Gastroenterology, 2010. https://doi.org/10.1053/j.gastro.2010.01.044
RethinkPeptides
RethinkPeptides Research Database. "Cholecystokinin knockout mice are resistant to high-fat diet..." RPEP-01653. Retrieved from https://rethinkpeptides.com/research/lo-2010-cholecystokinin-knockout-mice-are
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.