Apolipoprotein AIV interacted with CCK to synergistically reduce food intake in rats, with ApoAIV enhancing CCK's satiety signal — revealing a lipid-peptide cooperation for appetite suppression.
Key findingApoAIV enhanced CCK-mediated satiety signaling for synergistic food intake reduction in rats, with the interaction involving CCK-A receptor pathways —
What the researchers found
ApoAIV enhanced CCK-mediated satiety signaling for synergistic food intake reduction in rats, with the interaction involving CCK-A receptor pathways — demonstrating cooperation between lipid transport proteins and gut peptides for integrated appetite control.
Why it matters
Relevant for neuropeptides, weight-loss.
How the study worked
animal-study study on neuropeptides, weight-loss.
What this study cannot tell us
See abstract.
How to read the evidence
preliminary evidence.
When this study was published
Published in 2007.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Interaction of apolipoprotein AIV with cholecystokinin on the control of food intake.
American journal of physiology. Regulatory, integrative and comparative physiology, 293(4), R1490-4
Citation
Lo, Chun Min; Zhang, Dian Ming; Pearson, Kevin; Ma, Liyun; Sun, William; Sakai, Randall R; Davidson, W Sean; Liu, Min; Raybould, Helen E; Woods, Stephen C; Tso, Patrick. (2007). Interaction of apolipoprotein AIV with cholecystokinin on the control of food intake.. American journal of physiology. Regulatory, integrative and comparative physiology, 293(4), R1490-4.