How the Gut Protein ApoAIV and CCK Work Together to Control Meal Size
Apolipoprotein AIV interacted with CCK to synergistically reduce food intake in rats, with ApoAIV enhancing CCK's satiety signal — revealing a lipid-peptide cooperation for appetite suppression.
Quick Facts
What This Study Found
ApoAIV enhanced CCK-mediated satiety signaling for synergistic food intake reduction in rats, with the interaction involving CCK-A receptor pathways — demonstrating cooperation between lipid transport proteins and gut peptides for integrated appetite control.
Key Numbers
How They Did This
animal-study study on neuropeptides, weight-loss.
Why This Research Matters
Relevant for neuropeptides, weight-loss.
The Bigger Picture
Advances peptide research.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding ApoAIV enhanced CCK-mediated satiety signaling for synergistic food intake reduction in rats, with the interaction involving CCK-A receptor pathways —
- Evidence Grade:
- preliminary evidence.
- Study Age:
- Published in 2007.
- Original Title:
- Interaction of apolipoprotein AIV with cholecystokinin on the control of food intake.
- Published In:
- American journal of physiology. Regulatory, integrative and comparative physiology, 293(4), R1490-4 (2007)
- Authors:
- Lo, Chun Min, Zhang, Dian Ming, Pearson, Kevin, Ma, Liyun, Sun, William, Sakai, Randall R, Davidson, W Sean, Liu, Min, Raybould, Helen E, Woods, Stephen C, Tso, Patrick
- Database ID:
- RPEP-01261
Evidence Hierarchy
Tests effects in animals (usually mice or rats), not humans.
What do these levels mean? →Frequently Asked Questions
What was studied?
How the Gut Protein ApoAIV and CCK Work Together to Control Meal Size
What was found?
Apolipoprotein AIV interacted with CCK to synergistically reduce food intake in rats, with ApoAIV enhancing CCK's satiety signal — revealing a lipid-peptide cooperation for appetite suppression.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-01261APA
Lo, Chun Min; Zhang, Dian Ming; Pearson, Kevin; Ma, Liyun; Sun, William; Sakai, Randall R; Davidson, W Sean; Liu, Min; Raybould, Helen E; Woods, Stephen C; Tso, Patrick. (2007). Interaction of apolipoprotein AIV with cholecystokinin on the control of food intake.. American journal of physiology. Regulatory, integrative and comparative physiology, 293(4), R1490-4.
MLA
Lo, Chun Min, et al. "Interaction of apolipoprotein AIV with cholecystokinin on the control of food intake.." American journal of physiology. Regulatory, 2007.
RethinkPeptides
RethinkPeptides Research Database. "Interaction of apolipoprotein AIV with cholecystokinin on th..." RPEP-01261. Retrieved from https://rethinkpeptides.com/research/lo-2007-interaction-of-apolipoprotein-aiv
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.