Synthesized peptides 705-734 from hepatitis C virus E2 glycoprotein induce dendritic cell maturation by activating p38 MAPK signaling.
Quick Facts
What This Study Found
The synthesized 30 amino acid peptide (residues 705-734) from HCV E2 binds to dendritic cells via the DC-SIGN receptor, induces their maturation, increases IL-12, CD80, and CD86 production, decreases IL-10, and activates p38 MAPK signaling.
Key Numbers
How They Did This
The study synthesized a 30 amino acid peptide from HCV E2 using solid-phase peptide synthesis. Western blot and infection blocking assays confirmed peptide characteristics. ELISA and flow cytometry assessed dendritic cell responses and T cell activation after peptide treatment.
Why This Research Matters
Understanding how HCV peptides activate immune cells helps identify new targets for vaccines or inhibitors, potentially improving hepatitis C treatment and prevention.
What This Study Doesn't Tell Us
The study did not specify the sample size or in vivo validation, limiting understanding of clinical relevance. The exact signaling mechanisms require further exploration.
Trust & Context
- Original Title:
- Synthesized peptides 705-734 from hepatitis C virus E2 glycoprotein induce dendritic cell maturation by activating p38 MAPK signaling.
- Published In:
- International immunopharmacology, 30, 194-201 (2016)
- Authors:
- Liu, Xiaojing, Chen, Na, Lin, Shumei, Liu, Min
- Database ID:
- RPEP-03024
Evidence Hierarchy
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Cite This Study
https://rethinkpeptides.com/research/RPEP-03024APA
Liu, Xiaojing; Chen, Na; Lin, Shumei; Liu, Min. (2016). Synthesized peptides 705-734 from hepatitis C virus E2 glycoprotein induce dendritic cell maturation by activating p38 MAPK signaling.. International immunopharmacology, 30, 194-201. https://doi.org/10.1016/j.intimp.2015.11.009
MLA
Liu, Xiaojing, et al. "Synthesized peptides 705-734 from hepatitis C virus E2 glycoprotein induce dendritic cell maturation by activating p38 MAPK signaling.." International immunopharmacology, 2016. https://doi.org/10.1016/j.intimp.2015.11.009
RethinkPeptides
RethinkPeptides Research Database. "Synthesized peptides 705-734 from hepatitis C virus E2 glyco..." RPEP-03024. Retrieved from https://rethinkpeptides.com/research/liu-2016-synthesized-peptides-705734-from
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.