This record provides bibliographic details and links to the original research. An editorial study breakdown is not available.
What the researchers found
Serum substance P concentrations were significantly different between osteoarthritis and rheumatoid arthritis patients and positively correlated with chronic pain intensity in both groups.
Why it matters
Understanding the link between substance P and chronic pain could help develop targeted treatments for inflammatory joint diseases, improving pain management.
How the study worked
The study enrolled patients diagnosed with osteoarthritis and rheumatoid arthritis and measured their serum substance P levels. Pain intensity was assessed and correlated with substance P concentrations to evaluate their relationship.
What this study cannot tell us
The study type and evidence strength were not specified, and the sample size and control details are unclear, limiting the ability to generalize findings.
Read the original research
Substance P and Chronic Pain in Patients with Chronic Inflammation of Connective Tissue.
PloS one, 10(10), e0139206
Citation
Lisowska, Barbara; Lisowski, Aleksander; Siewruk, Katarzyna. (2015). Substance P and Chronic Pain in Patients with Chronic Inflammation of Connective Tissue.. PloS one, 10(10), e0139206. https://doi.org/10.1371/journal.pone.0139206