Basal insulin intensification with GLP-1RA and dual GIP and GLP-1RA in patients with uncontrolled type 2 diabetes mellitus: A rapid review of randomized controlled trials and meta-analysis.
Quick Facts
What This Study Found
Tirzepatide reduced HbA1c by 1% and body weight by 3.95 kg without increasing hypoglycemia risk.
Key Numbers
How They Did This
The study is a systematic review and meta-analysis of eleven randomized controlled trials.
Why This Research Matters
This research highlights a new effective treatment option for patients with uncontrolled type 2 diabetes, addressing both glucose control and weight management.
What This Study Doesn't Tell Us
The review is based on existing trials, which may vary in quality and design, potentially affecting the generalizability of the findings.
Trust & Context
- Original Title:
- Basal insulin intensification with GLP-1RA and dual GIP and GLP-1RA in patients with uncontrolled type 2 diabetes mellitus: A rapid review of randomized controlled trials and meta-analysis.
- Published In:
- Frontiers in endocrinology, 13, 920541 (2022)
- Authors:
- Lisco, Giuseppe, De Tullio, Anna, Disoteo, Olga, De Geronimo, Vincenzo, Piazzolla, Giuseppina, De Pergola, Giovanni, Giagulli, Vito Angelo, Jirillo, Emilio, Guastamacchia, Edoardo, Sabbà, Carlo, Triggiani, Vincenzo
- Database ID:
- RPEP-06317
Evidence Hierarchy
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Cite This Study
https://rethinkpeptides.com/research/RPEP-06317APA
Lisco, Giuseppe; De Tullio, Anna; Disoteo, Olga; De Geronimo, Vincenzo; Piazzolla, Giuseppina; De Pergola, Giovanni; Giagulli, Vito Angelo; Jirillo, Emilio; Guastamacchia, Edoardo; Sabbà, Carlo; Triggiani, Vincenzo. (2022). Basal insulin intensification with GLP-1RA and dual GIP and GLP-1RA in patients with uncontrolled type 2 diabetes mellitus: A rapid review of randomized controlled trials and meta-analysis.. Frontiers in endocrinology, 13, 920541. https://doi.org/10.3389/fendo.2022.920541
MLA
Lisco, Giuseppe, et al. "Basal insulin intensification with GLP-1RA and dual GIP and GLP-1RA in patients with uncontrolled type 2 diabetes mellitus: A rapid review of randomized controlled trials and meta-analysis.." Frontiers in endocrinology, 2022. https://doi.org/10.3389/fendo.2022.920541
RethinkPeptides
RethinkPeptides Research Database. "Basal insulin intensification with GLP-1RA and dual GIP and ..." RPEP-06317. Retrieved from https://rethinkpeptides.com/research/lisco-2022-basal-insulin-intensification-with
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.