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Study breakdown

BDNF and TrkB Increase in Pain-Sensing Nerves During Inflammation

evidence
The takeaway

BDNF and its TrkB receptor were upregulated in dorsal root ganglia during inflammatory pain in vivo and in vitro, establishing the BDNF-TrkB axis as a contributor to inflammatory pain sensitization.

Key finding

BDNF and its TrkB receptor were upregulated in dorsal root ganglia during inflammatory pain in vivo and in vitro, establishing the BDNF-TrkB axis as a

What the researchers found

BDNF and its TrkB receptor were upregulated in dorsal root ganglia during inflammatory pain in vivo and in vitro, establishing the BDNF-TrkB axis as a contributor to inflammatory pain sensitization.

Why it matters

Relevant for peptide research.

How the study worked

research study.

What this study cannot tell us

See abstract.

How to read the evidence

emerging evidence.

When this study was published

Published in 2011.

The bigger picture

Advances peptide research.

Questions still open

  • Further research needed.

Common questions

What was studied?
BDNF and TrkB Increase in Pain-Sensing Nerves During Inflammation
What was found?
BDNF and its TrkB receptor were upregulated in dorsal root ganglia during inflammatory pain in vivo and in vitro, establishing the BDNF-TrkB axis as a contributor to inflammatory pain sensitization.

Read the original research

Up-regulation of dorsal root ganglia BDNF and trkB receptor in inflammatory pain: an in vivo and in vitro study.

Journal of neuroinflammation, 8, 126

Citation

Lin, Ya-Tin; Ro, Long-Sun; Wang, Hung-Li; Chen, Jin-Chung. (2011). Up-regulation of dorsal root ganglia BDNF and trkB receptor in inflammatory pain: an in vivo and in vitro study.. Journal of neuroinflammation, 8, 126. https://doi.org/10.1186/1742-2094-8-126