Substance P promotes the progression of bronchial asthma through activating the PI3K/AKT/NF-κB pathway mediated cellular inflammation and pyroptotic cell death in bronchial epithelial cells.
Quick Facts
What This Study Found
Substance P increased pyroptotic cell death and inflammation in bronchial cells, activating the PI3K/AKT/NF-κB pathway.
Key Numbers
How They Did This
The study used clinical data from asthma patients and pre-clinical experiments with bronchial epithelial cells and asthmatic mice models to analyze the effects of Substance P.
Why This Research Matters
Understanding how Substance P exacerbates asthma could lead to new therapeutic approaches to manage the condition. Targeting the pathways involved may help reduce inflammation and improve patient outcomes.
What This Study Doesn't Tell Us
The study primarily focuses on in vitro and animal models, which may not fully represent human asthma pathology.
Trust & Context
- Original Title:
- Substance P promotes the progression of bronchial asthma through activating the PI3K/AKT/NF-κB pathway mediated cellular inflammation and pyroptotic cell death in bronchial epithelial cells.
- Published In:
- Cell cycle (Georgetown, Tex.), 21(20), 2179-2191 (2022)
- Authors:
- Li, Miao, Zhong, Xiao, Xu, Wen-Ting
- Database ID:
- RPEP-06302
Evidence Hierarchy
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Cite This Study
https://rethinkpeptides.com/research/RPEP-06302APA
Li, Miao; Zhong, Xiao; Xu, Wen-Ting. (2022). Substance P promotes the progression of bronchial asthma through activating the PI3K/AKT/NF-κB pathway mediated cellular inflammation and pyroptotic cell death in bronchial epithelial cells.. Cell cycle (Georgetown, Tex.), 21(20), 2179-2191. https://doi.org/10.1080/15384101.2022.2092166
MLA
Li, Miao, et al. "Substance P promotes the progression of bronchial asthma through activating the PI3K/AKT/NF-κB pathway mediated cellular inflammation and pyroptotic cell death in bronchial epithelial cells.." Cell cycle (Georgetown, 2022. https://doi.org/10.1080/15384101.2022.2092166
RethinkPeptides
RethinkPeptides Research Database. "Substance P promotes the progression of bronchial asthma thr..." RPEP-06302. Retrieved from https://rethinkpeptides.com/research/li-2022-substance-p-promotes-the
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.