Ghrelin Protects Blood Vessel Cells by Blocking Inflammation Through NF-κB Inhibition
Ghrelin directly inhibited TNF-α-induced pro-inflammatory responses and NF-κB nuclear translocation in human endothelial cells, revealing a specific molecular mechanism for ghrelin's cardiovascular protective anti-inflammatory effect.
Quick Facts
What This Study Found
Ghrelin inhibited TNF-α-induced VCAM-1, ICAM-1, and MCP-1 expression in human endothelial cells by blocking NF-κB nuclear translocation via IκBα preservation — a specific anti-inflammatory mechanism protecting blood vessels from atherosclerosis.
Key Numbers
How They Did This
in-vitro study examining ghrp and cardiovascular.
Why This Research Matters
Advances understanding of ghrp, cardiovascular, inflammation, receptor-signaling.
The Bigger Picture
Contributes to peptide research with clinical implications.
What This Study Doesn't Tell Us
Study-specific limitations; see abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation potential to evaluate.
Trust & Context
- Key Stat:
- Key finding Ghrelin inhibited TNF-α-induced VCAM-1, ICAM-1, and MCP-1 expression in human endothelial cells by blocking NF-κB nuclear translocation via IκBα prese
- Evidence Grade:
- moderate evidence from in-vitro study.
- Study Age:
- Published in 2004.
- Original Title:
- Ghrelin inhibits proinflammatory responses and nuclear factor-kappaB activation in human endothelial cells.
- Published In:
- Circulation, 109(18), 2221-6 (2004)
- Authors:
- Li, Wei Gen, Gavrila, Dan, Liu, Xuebo(2), Wang, Lixing, Gunnlaugsson, Skuli, Stoll, Lynn L, McCormick, Michael L, Sigmund, Curt D, Tang, Chaosu, Weintraub, Neal L
- Database ID:
- RPEP-00940
Evidence Hierarchy
Frequently Asked Questions
What was studied?
Ghrelin Protects Blood Vessel Cells by Blocking Inflammation Through NF-κB Inhibition
What was found?
Ghrelin directly inhibited TNF-α-induced pro-inflammatory responses and NF-κB nuclear translocation in human endothelial cells, revealing a specific molecular mechanism for ghrelin's cardiovascular protective anti-inflammatory effect.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-00940APA
Li, Wei Gen; Gavrila, Dan; Liu, Xuebo; Wang, Lixing; Gunnlaugsson, Skuli; Stoll, Lynn L; McCormick, Michael L; Sigmund, Curt D; Tang, Chaosu; Weintraub, Neal L. (2004). Ghrelin inhibits proinflammatory responses and nuclear factor-kappaB activation in human endothelial cells.. Circulation, 109(18), 2221-6.
MLA
Li, Wei Gen, et al. "Ghrelin inhibits proinflammatory responses and nuclear factor-kappaB activation in human endothelial cells.." Circulation, 2004.
RethinkPeptides
RethinkPeptides Research Database. "Ghrelin inhibits proinflammatory responses and nuclear facto..." RPEP-00940. Retrieved from https://rethinkpeptides.com/research/li-2004-ghrelin-inhibits-proinflammatory-responses
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.