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Study breakdown

CCK-8 Activates mTOR Signaling in Hypothalamic Appetite Neurons

evidence
The takeaway

Sulfated CCK-8 activated phospho-mTOR immunoreactive neurons in the paraventricular nucleus, linking the satiety hormone to mTOR nutrient-sensing pathways in appetite-controlling brain regions.

Key finding

Sulfated CCK-8 activated phospho-mTOR immunoreactive neurons in the paraventricular nucleus, linking the satiety hormone to mTOR nutrient-sensing path

What the researchers found

Sulfated CCK-8 activated phospho-mTOR immunoreactive neurons in the paraventricular nucleus, linking the satiety hormone to mTOR nutrient-sensing pathways in appetite-controlling brain regions.

Why it matters

Relevant for peptide research.

How the study worked

research study.

What this study cannot tell us

See abstract.

How to read the evidence

emerging evidence.

When this study was published

Published in 2011.

The bigger picture

Advances peptide research.

Questions still open

  • Further research needed.

Common questions

What was studied?
CCK-8 Activates mTOR Signaling in Hypothalamic Appetite Neurons
What was found?
Sulfated CCK-8 activated phospho-mTOR immunoreactive neurons in the paraventricular nucleus, linking the satiety hormone to mTOR nutrient-sensing pathways in appetite-controlling brain regions.

Read the original research

Sulfated cholecystokinin-8 activates phospho-mTOR immunoreactive neurons of the paraventricular nucleus in rats.

Peptides, 32(1), 65-70

Citation

Lembke, Vanessa; Goebel, Miriam; Frommelt, Lisa; Inhoff, Tobias; Lommel, Reinhardt; Stengel, Andreas; Taché, Yvette; Grötzinger, Carsten; Bannert, Norbert; Wiedenmann, Bertram; Klapp, Burghard F; Kobelt, Peter. (2011). Sulfated cholecystokinin-8 activates phospho-mTOR immunoreactive neurons of the paraventricular nucleus in rats.. Peptides, 32(1), 65-70. https://doi.org/10.1016/j.peptides.2010.09.025