MOTS-c: A novel mitochondrial-derived peptide regulating muscle and fat metabolism.

MOTS-c, a mitochondrial-derived peptide encoded by mitochondrial DNA, targets skeletal muscle to enhance glucose metabolism and regulate fat metabolism. This peptide represents a novel mitochondrial signaling mechanism with potential roles in obesity, diabetes, exercise, and longevity.

The study reviewed existing research on mitochondrial DNA-encoded peptides, focusing on MOTS-c’s biological activities and metabolic effects, particularly its role in skeletal muscle glucose metabolism.

Discovering MOTS-c expands our understanding of mitochondrial signaling in metabolism, offering new targets for treating metabolic disorders and improving muscle function.

The study is primarily a review and does not provide new experimental data; the exact mechanisms and clinical applications of MOTS-c require further investigation.