This record provides bibliographic details and links to the original research. An editorial study breakdown is not available.
What the researchers found
MOTS-c, a mitochondrial-derived peptide encoded by mitochondrial DNA, targets skeletal muscle to enhance glucose metabolism and regulate fat metabolism. This peptide represents a novel mitochondrial signaling mechanism with potential roles in obesity, diabetes, exercise, and longevity.
Why it matters
Discovering MOTS-c expands our understanding of mitochondrial signaling in metabolism, offering new targets for treating metabolic disorders and improving muscle function.
How the study worked
The study reviewed existing research on mitochondrial DNA-encoded peptides, focusing on MOTS-c’s biological activities and metabolic effects, particularly its role in skeletal muscle glucose metabolism.
What this study cannot tell us
The study is primarily a review and does not provide new experimental data; the exact mechanisms and clinical applications of MOTS-c require further investigation.
Read the original research
MOTS-c: A novel mitochondrial-derived peptide regulating muscle and fat metabolism.
Free radical biology & medicine, 100, 182-187
Citation
Lee, Changhan; Kim, Kyung Hwa; Cohen, Pinchas. (2016). MOTS-c: A novel mitochondrial-derived peptide regulating muscle and fat metabolism.. Free radical biology & medicine, 100, 182-187. https://doi.org/10.1016/j.freeradbiomed.2016.05.015