Obese subjects had attenuated PYY3-36 release after meals compared to lean controls, with the blunted PYY associated with reduced subjective satiety — explaining why obese individuals feel less full after eating.
Key findingObese subjects demonstrated attenuated postprandial PYY3-36 release compared to lean controls, with reduced PYY correlating with diminished subjective
What the researchers found
Obese subjects demonstrated attenuated postprandial PYY3-36 release compared to lean controls, with reduced PYY correlating with diminished subjective satiety — PYY deficiency contributes to impaired meal-related fullness signaling in obesity.
Why it matters
Relevant for neuropeptides, weight-loss.
How the study worked
clinical-trial study on neuropeptides, weight-loss.
What this study cannot tell us
See abstract.
How to read the evidence
strong evidence.
When this study was published
Published in 2006.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Attenuated peptide YY release in obese subjects is associated with reduced satiety.
Endocrinology, 147(1), 3-8
Citation
le Roux, C W; Batterham, R L; Aylwin, S J B; Patterson, M; Borg, C M; Wynne, K J; Kent, A; Vincent, R P; Gardiner, J; Ghatei, M A; Bloom, S R. (2006). Attenuated peptide YY release in obese subjects is associated with reduced satiety.. Endocrinology, 147(1), 3-8.