Obese People Release Less PYY After Meals — Explaining Their Reduced Satiety
Obese subjects had attenuated PYY3-36 release after meals compared to lean controls, with the blunted PYY associated with reduced subjective satiety — explaining why obese individuals feel less full after eating.
Quick Facts
What This Study Found
Obese subjects demonstrated attenuated postprandial PYY3-36 release compared to lean controls, with reduced PYY correlating with diminished subjective satiety — PYY deficiency contributes to impaired meal-related fullness signaling in obesity.
Key Numbers
How They Did This
clinical-trial study on neuropeptides, weight-loss.
Why This Research Matters
Relevant for neuropeptides, weight-loss.
The Bigger Picture
Advances peptide research.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding Obese subjects demonstrated attenuated postprandial PYY3-36 release compared to lean controls, with reduced PYY correlating with diminished subjective
- Evidence Grade:
- strong evidence.
- Study Age:
- Published in 2006.
- Original Title:
- Attenuated peptide YY release in obese subjects is associated with reduced satiety.
- Published In:
- Endocrinology, 147(1), 3-8 (2006)
- Authors:
- le Roux, C W(2), Batterham, R L(2), Aylwin, S J B(2), Patterson, M, Borg, C M, Wynne, K J, Kent, A, Vincent, R P, Gardiner, J, Ghatei, M A, Bloom, S R
- Database ID:
- RPEP-01160
Evidence Hierarchy
Frequently Asked Questions
What was studied?
Obese People Release Less PYY After Meals — Explaining Their Reduced Satiety
What was found?
Obese subjects had attenuated PYY3-36 release after meals compared to lean controls, with the blunted PYY associated with reduced subjective satiety — explaining why obese individuals feel less full after eating.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-01160APA
le Roux, C W; Batterham, R L; Aylwin, S J B; Patterson, M; Borg, C M; Wynne, K J; Kent, A; Vincent, R P; Gardiner, J; Ghatei, M A; Bloom, S R. (2006). Attenuated peptide YY release in obese subjects is associated with reduced satiety.. Endocrinology, 147(1), 3-8.
MLA
le Roux, C W, et al. "Attenuated peptide YY release in obese subjects is associated with reduced satiety.." Endocrinology, 2006.
RethinkPeptides
RethinkPeptides Research Database. "Attenuated peptide YY release in obese subjects is associate..." RPEP-01160. Retrieved from https://rethinkpeptides.com/research/le-2006-attenuated-peptide-yy-release
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.