Substance P/neurokinin-1 receptor pathway blockade ameliorates limbal stem cell deficiency by modulating mTOR pathway and preventing cell senescence.
Quick Facts
What This Study Found
SP ablation or NK1R blockade increased epithelial wound healing (p < 0.001) and corneal transparency (p < 0.001).
Key Numbers
How They Did This
The study used a pre-clinical model to evaluate the effects of SP ablation and NK1R blockade on corneal epithelium wound healing.
Why This Research Matters
Improving healing in LSCD could enhance patient outcomes for severe ocular surface diseases. This research opens avenues for new treatments targeting the SP/NK1R pathway.
What This Study Doesn't Tell Us
The study is pre-clinical, and results may not directly translate to human patients.
Trust & Context
- Original Title:
- Substance P/neurokinin-1 receptor pathway blockade ameliorates limbal stem cell deficiency by modulating mTOR pathway and preventing cell senescence.
- Published In:
- Stem cell reports, 17(4), 849-863 (2022)
- Authors:
- Lasagni Vitar, Romina, Triani, Francesca, Barbariga, Marco, Fonteyne, Philippe, Rama, Paolo, Ferrari, Giulio
- Database ID:
- RPEP-06287
Evidence Hierarchy
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Cite This Study
https://rethinkpeptides.com/research/RPEP-06287APA
Lasagni Vitar, Romina; Triani, Francesca; Barbariga, Marco; Fonteyne, Philippe; Rama, Paolo; Ferrari, Giulio. (2022). Substance P/neurokinin-1 receptor pathway blockade ameliorates limbal stem cell deficiency by modulating mTOR pathway and preventing cell senescence.. Stem cell reports, 17(4), 849-863. https://doi.org/10.1016/j.stemcr.2022.02.012
MLA
Lasagni Vitar, Romina, et al. "Substance P/neurokinin-1 receptor pathway blockade ameliorates limbal stem cell deficiency by modulating mTOR pathway and preventing cell senescence.." Stem cell reports, 2022. https://doi.org/10.1016/j.stemcr.2022.02.012
RethinkPeptides
RethinkPeptides Research Database. "Substance P/neurokinin-1 receptor pathway blockade ameliorat..." RPEP-06287. Retrieved from https://rethinkpeptides.com/research/lasagni-2022-substance-pneurokinin1-receptor-pathway
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.