This record provides bibliographic details and links to the original research. An editorial study breakdown is not available.
What the researchers found
SP ablation or NK1R blockade increased epithelial wound healing (p < 0.001) and corneal transparency (p < 0.001).
Why it matters
Improving healing in LSCD could enhance patient outcomes for severe ocular surface diseases. This research opens avenues for new treatments targeting the SP/NK1R pathway.
How the study worked
The study used a pre-clinical model to evaluate the effects of SP ablation and NK1R blockade on corneal epithelium wound healing.
What this study cannot tell us
The study is pre-clinical, and results may not directly translate to human patients.
Read the original research
Substance P/neurokinin-1 receptor pathway blockade ameliorates limbal stem cell deficiency by modulating mTOR pathway and preventing cell senescence.
Stem cell reports, 17(4), 849-863
Citation
Lasagni Vitar, Romina; Triani, Francesca; Barbariga, Marco; Fonteyne, Philippe; Rama, Paolo; Ferrari, Giulio. (2022). Substance P/neurokinin-1 receptor pathway blockade ameliorates limbal stem cell deficiency by modulating mTOR pathway and preventing cell senescence.. Stem cell reports, 17(4), 849-863. https://doi.org/10.1016/j.stemcr.2022.02.012