This record provides bibliographic details and links to the original research. An editorial study breakdown is not available.
What the researchers found
KBP-336 was superior to cagrilintide in inducing weight loss and improving glucose control in rats.
Why it matters
These findings suggest that receptor balance is crucial for the effectiveness of weight loss and diabetes treatments, potentially guiding future drug development.
How the study worked
The study involved in vitro receptor activation assays and in vivo tests on obese and diabetic rat models.
What this study cannot tell us
The study was conducted in preclinical models, so results may not directly translate to humans.
Read the original research
Does receptor balance matter? - Comparing the efficacies of the dual amylin and calcitonin receptor agonists cagrilintide and KBP-336 on metabolic parameters in preclinical models.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 156, 113842
Citation
Larsen, A T; Mohamed, K E; Sonne, N; Bredtoft, E; Andersen, F; Karsdal, M A; Henriksen, K. (2022). Does receptor balance matter? - Comparing the efficacies of the dual amylin and calcitonin receptor agonists cagrilintide and KBP-336 on metabolic parameters in preclinical models.. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 156, 113842. https://doi.org/10.1016/j.biopha.2022.113842