Does receptor balance matter? - Comparing the efficacies of the dual amylin and calcitonin receptor agonists cagrilintide and KBP-336 on metabolic parameters in preclinical models.
Quick Facts
What This Study Found
KBP-336 was superior to cagrilintide in inducing weight loss and improving glucose control in rats.
Key Numbers
How They Did This
The study involved in vitro receptor activation assays and in vivo tests on obese and diabetic rat models.
Why This Research Matters
These findings suggest that receptor balance is crucial for the effectiveness of weight loss and diabetes treatments, potentially guiding future drug development.
What This Study Doesn't Tell Us
The study was conducted in preclinical models, so results may not directly translate to humans.
Trust & Context
- Original Title:
- Does receptor balance matter? - Comparing the efficacies of the dual amylin and calcitonin receptor agonists cagrilintide and KBP-336 on metabolic parameters in preclinical models.
- Published In:
- Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 156, 113842 (2022)
- Authors:
- Larsen, A T, Mohamed, K E, Sonne, N, Bredtoft, E, Andersen, F, Karsdal, M A, Henriksen, K
- Database ID:
- RPEP-06286
Evidence Hierarchy
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Cite This Study
https://rethinkpeptides.com/research/RPEP-06286APA
Larsen, A T; Mohamed, K E; Sonne, N; Bredtoft, E; Andersen, F; Karsdal, M A; Henriksen, K. (2022). Does receptor balance matter? - Comparing the efficacies of the dual amylin and calcitonin receptor agonists cagrilintide and KBP-336 on metabolic parameters in preclinical models.. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 156, 113842. https://doi.org/10.1016/j.biopha.2022.113842
MLA
Larsen, A T, et al. "Does receptor balance matter? - Comparing the efficacies of the dual amylin and calcitonin receptor agonists cagrilintide and KBP-336 on metabolic parameters in preclinical models.." Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022. https://doi.org/10.1016/j.biopha.2022.113842
RethinkPeptides
RethinkPeptides Research Database. "Does receptor balance matter? - Comparing the efficacies of ..." RPEP-06286. Retrieved from https://rethinkpeptides.com/research/larsen-2022-does-receptor-balance-matter
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.