The Evolution of NPY Receptors: From One Ancient Receptor to Five Modern Subtypes
NPY receptor subtypes (Y1-Y5) evolved through gene duplication from an ancestral receptor, with each subtype acquiring distinct tissue distribution and function — explaining NPY's diverse roles in appetite, anxiety, blood pressure, and circadian rhythm.
Quick Facts
What This Study Found
NPY receptor subtypes Y1-Y5 evolved through ancient gene duplications, with each acquiring distinct tissue distribution and functional specialization — Y1 for anxiety/vasoconstriction, Y2 for presynaptic inhibition, Y4 for PP binding, Y5 for feeding.
Key Numbers
How They Did This
review study examining neuropeptides and receptor-signaling.
Why This Research Matters
Advances understanding of neuropeptides, receptor-signaling, peptide-design.
The Bigger Picture
Contributes to peptide research with clinical implications.
What This Study Doesn't Tell Us
Study-specific limitations; see abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation potential to evaluate.
Trust & Context
- Key Stat:
- Key finding NPY receptor subtypes Y1-Y5 evolved through ancient gene duplications, with each acquiring distinct tissue distribution and functional specialization
- Evidence Grade:
- moderate evidence from review study.
- Study Age:
- Published in 2004.
- Original Title:
- Molecular evolution of NPY receptor subtypes.
- Published In:
- Neuropeptides, 38(4), 141-51 (2004)
- Authors:
- Larhammar, D, Salaneck, E
- Database ID:
- RPEP-00937
Evidence Hierarchy
Summarizes existing research on a topic.
What do these levels mean? →Frequently Asked Questions
What was studied?
The Evolution of NPY Receptors: From One Ancient Receptor to Five Modern Subtypes
What was found?
NPY receptor subtypes (Y1-Y5) evolved through gene duplication from an ancestral receptor, with each subtype acquiring distinct tissue distribution and function — explaining NPY's diverse roles in appetite, anxiety, blood pressure, and circadian rhythm.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-00937APA
Larhammar, D; Salaneck, E. (2004). Molecular evolution of NPY receptor subtypes.. Neuropeptides, 38(4), 141-51.
MLA
Larhammar, D, et al. "Molecular evolution of NPY receptor subtypes.." Neuropeptides, 2004.
RethinkPeptides
RethinkPeptides Research Database. "Molecular evolution of NPY receptor subtypes." RPEP-00937. Retrieved from https://rethinkpeptides.com/research/larhammar-2004-molecular-evolution-of-npy
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.