Genetic polymorphisms in the pro-ghrelin and GHS-R1A genes were associated with heavy alcohol use and body mass in a human population study, linking ghrelin system genetics to both addiction and obesity risk.
Key findingPro-ghrelin and GHS-R1A gene polymorphisms and haplotypes were associated with heavy alcohol use and BMI in humans, providing genetic evidence linking
What the researchers found
Pro-ghrelin and GHS-R1A gene polymorphisms and haplotypes were associated with heavy alcohol use and BMI in humans, providing genetic evidence linking the ghrelin system to both alcohol addiction vulnerability and body weight regulation.
Why it matters
Relevant for neuropeptides, addiction, hormone-optimization.
How the study worked
cross-sectional study.
What this study cannot tell us
See abstract.
How to read the evidence
preliminary evidence.
When this study was published
Published in 2008.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Association of pro-ghrelin and GHS-R1A gene polymorphisms and haplotypes with heavy alcohol use and body mass.
Alcoholism, clinical and experimental research, 32(12), 2054-61
Citation
Landgren, Sara; Jerlhag, Elisabet; Zetterberg, Henrik; Gonzalez-Quintela, Arturo; Campos, Joaquin; Olofsson, Ulrica; Nilsson, Staffan; Blennow, Kaj; Engel, Jörgen A. (2008). Association of pro-ghrelin and GHS-R1A gene polymorphisms and haplotypes with heavy alcohol use and body mass.. Alcoholism, clinical and experimental research, 32(12), 2054-61. https://doi.org/10.1111/j.1530-0277.2008.00793.x