Targeting an alternate Wilms' tumor antigen 1 peptide bypasses immunoproteasome dependency.
Quick Facts
What This Study Found
The new TCR (TTCR37-45) effectively killed relapsed AML cells resistant to previous targeting.
Key Numbers
How They Did This
The study involved analyzing patient samples and testing T cell receptors in vitro and in a mouse model.
Why This Research Matters
Understanding how leukemia cells evade immune targeting can lead to more effective therapies. This research opens new avenues for treating resistant forms of leukemia.
What This Study Doesn't Tell Us
The study primarily focuses on a small number of patients and in vitro models, which may limit generalizability.
Trust & Context
- Original Title:
- Targeting an alternate Wilms' tumor antigen 1 peptide bypasses immunoproteasome dependency.
- Published In:
- Science translational medicine, 14(631), eabg8070 (2022)
- Authors:
- Lahman, Miranda C, Schmitt, Thomas M, Paulson, Kelly G, Vigneron, Nathalie, Buenrostro, Denise, Wagener, Felecia D, Voillet, Valentin, Martin, Lauren, Gottardo, Raphael, Bielas, Jason, McElrath, Julie M, Stirewalt, Derek L, Pogosova-Agadjanyan, Era L, Yeung, Cecilia C, Pierce, Robert H, Egan, Daniel N, Bar, Merav, Hendrie, Paul C, Kinsella, Sinéad, Vakil, Aesha, Butler, Jonah, Chaffee, Mary, Linton, Jonathan, McAfee, Megan S, Hunter, Daniel S, Bleakley, Marie, Rongvaux, Anthony, Van den Eynde, Benoit J, Chapuis, Aude G, Greenberg, Philip D
- Database ID:
- RPEP-06283
Evidence Hierarchy
Read More on RethinkPeptides
Related articles coming soon.
Cite This Study
https://rethinkpeptides.com/research/RPEP-06283APA
Lahman, Miranda C; Schmitt, Thomas M; Paulson, Kelly G; Vigneron, Nathalie; Buenrostro, Denise; Wagener, Felecia D; Voillet, Valentin; Martin, Lauren; Gottardo, Raphael; Bielas, Jason; McElrath, Julie M; Stirewalt, Derek L; Pogosova-Agadjanyan, Era L; Yeung, Cecilia C; Pierce, Robert H; Egan, Daniel N; Bar, Merav; Hendrie, Paul C; Kinsella, Sinéad; Vakil, Aesha; Butler, Jonah; Chaffee, Mary; Linton, Jonathan; McAfee, Megan S; Hunter, Daniel S; Bleakley, Marie; Rongvaux, Anthony; Van den Eynde, Benoit J; Chapuis, Aude G; Greenberg, Philip D. (2022). Targeting an alternate Wilms' tumor antigen 1 peptide bypasses immunoproteasome dependency.. Science translational medicine, 14(631), eabg8070. https://doi.org/10.1126/scitranslmed.abg8070
MLA
Lahman, Miranda C, et al. "Targeting an alternate Wilms' tumor antigen 1 peptide bypasses immunoproteasome dependency.." Science translational medicine, 2022. https://doi.org/10.1126/scitranslmed.abg8070
RethinkPeptides
RethinkPeptides Research Database. "Targeting an alternate Wilms' tumor antigen 1 peptide bypass..." RPEP-06283. Retrieved from https://rethinkpeptides.com/research/lahman-2022-targeting-an-alternate-wilms
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.