Obese subjects responded to GHRP-2's appetite-stimulating effect comparably to lean individuals, showing no ghrelin resistance for appetite — contrary to the hypothesis that obesity blocks ghrelin's appetite effects.
Key findingObese subjects showed comparable food intake stimulation from GHRP-2 as lean controls, demonstrating preserved ghrelin appetite sensitivity despite ob
What the researchers found
Obese subjects showed comparable food intake stimulation from GHRP-2 as lean controls, demonstrating preserved ghrelin appetite sensitivity despite obesity — challenging the ghrelin resistance hypothesis and confirming appetite stimulation is a persistent GHS class effect.
Why it matters
Relevant for ghrp, weight-loss.
How the study worked
RCT study on ghrp, weight-loss.
What this study cannot tell us
See abstract.
How to read the evidence
strong evidence.
When this study was published
Published in 2006.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Obese subjects respond to the stimulatory effect of the ghrelin agonist growth hormone-releasing peptide-2 on food intake.
Obesity (Silver Spring, Md.), 14(6), 1056-63
Citation
Laferrère, Blandine; Hart, Allison B; Bowers, Cyril Y. (2006). Obese subjects respond to the stimulatory effect of the ghrelin agonist growth hormone-releasing peptide-2 on food intake.. Obesity (Silver Spring, Md.), 14(6), 1056-63.