Obese People Are NOT Resistant to GHRP-2's Appetite-Stimulating Effect
Obese subjects responded to GHRP-2's appetite-stimulating effect comparably to lean individuals, showing no ghrelin resistance for appetite — contrary to the hypothesis that obesity blocks ghrelin's appetite effects.
Quick Facts
What This Study Found
Obese subjects showed comparable food intake stimulation from GHRP-2 as lean controls, demonstrating preserved ghrelin appetite sensitivity despite obesity — challenging the ghrelin resistance hypothesis and confirming appetite stimulation is a persistent GHS class effect.
Key Numbers
How They Did This
RCT study on ghrp, weight-loss.
Why This Research Matters
Relevant for ghrp, weight-loss.
The Bigger Picture
Advances peptide research.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding Obese subjects showed comparable food intake stimulation from GHRP-2 as lean controls, demonstrating preserved ghrelin appetite sensitivity despite ob
- Evidence Grade:
- strong evidence.
- Study Age:
- Published in 2006.
- Original Title:
- Obese subjects respond to the stimulatory effect of the ghrelin agonist growth hormone-releasing peptide-2 on food intake.
- Published In:
- Obesity (Silver Spring, Md.), 14(6), 1056-63 (2006)
- Authors:
- Laferrère, Blandine(2), Hart, Allison B, Bowers, Cyril Y(20)
- Database ID:
- RPEP-01158
Evidence Hierarchy
Frequently Asked Questions
What was studied?
Obese People Are NOT Resistant to GHRP-2's Appetite-Stimulating Effect
What was found?
Obese subjects responded to GHRP-2's appetite-stimulating effect comparably to lean individuals, showing no ghrelin resistance for appetite — contrary to the hypothesis that obesity blocks ghrelin's appetite effects.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-01158APA
Laferrère, Blandine; Hart, Allison B; Bowers, Cyril Y. (2006). Obese subjects respond to the stimulatory effect of the ghrelin agonist growth hormone-releasing peptide-2 on food intake.. Obesity (Silver Spring, Md.), 14(6), 1056-63.
MLA
Laferrère, Blandine, et al. "Obese subjects respond to the stimulatory effect of the ghrelin agonist growth hormone-releasing peptide-2 on food intake.." Obesity (Silver Spring, 2006.
RethinkPeptides
RethinkPeptides Research Database. "Obese subjects respond to the stimulatory effect of the ghre..." RPEP-01158. Retrieved from https://rethinkpeptides.com/research/laferrere-2006-obese-subjects-respond-to
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.