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Study breakdown

GHRP-2 Increases Food Intake in Healthy Men — Confirming the Appetite Side Effect in Humans

Clinical TrialModerate evidence
The takeaway

Intravenous GHRP-2 significantly increased food intake and hunger ratings in healthy men alongside GH release, directly confirming the orexigenic effect of GH secretagogues in humans — not just animals.

Key finding

IV GHRP-2 increased food intake by ~35% and hunger VAS scores in healthy men in a controlled study, directly confirming the appetite-stimulating effec

What the researchers found

IV GHRP-2 increased food intake by ~35% and hunger VAS scores in healthy men in a controlled study, directly confirming the appetite-stimulating effect of GH secretagogues in humans alongside potent GH/cortisol release.

Why it matters

Relevant for ghrp, hormone-optimization.

How the study worked

clinical-trial study on ghrp, hormone-optimization.

What this study cannot tell us

See abstract.

How to read the evidence

moderate evidence.

When this study was published

Published in 2005.

The bigger picture

Advances peptide research with clinical implications.

Questions still open

  • Further research needed.
  • Clinical translation to evaluate.

Common questions

What was studied?
GHRP-2 Increases Food Intake in Healthy Men — Confirming the Appetite Side Effect in Humans
What was found?
Intravenous GHRP-2 significantly increased food intake and hunger ratings in healthy men alongside GH release, directly confirming the orexigenic effect of GH secretagogues in humans — not just animals.

Read the original research

Growth hormone releasing peptide-2 (GHRP-2), like ghrelin, increases food intake in healthy men.

The Journal of clinical endocrinology and metabolism, 90(2), 611-4

Citation

Laferrère, Blandine; Abraham, Cynthia; Russell, Colleen D; Bowers, Cyril Y. (2005). Growth hormone releasing peptide-2 (GHRP-2), like ghrelin, increases food intake in healthy men.. The Journal of clinical endocrinology and metabolism, 90(2), 611-4.