Immune Cells Release Opioid Peptides That Protect Against Nerve Pain

Immune cell-derived opioid peptides protected against neuropathic pain in mice, demonstrating that the peripheral immune-opioid system is effective not just for inflammatory pain but also for nerve injury pain.

Labuz, Dominika et al.·The Journal of clinical investigation·2009·
RPEP-015102009RETHINKTHC RESEARCH DATABASErethinkthc.com/research

Quick Facts

Study Type
Not classified
Evidence
Not graded
Sample
Not reported

What This Study Found

Immune cell-derived opioid peptides protected against neuropathic pain in mice, demonstrating that the peripheral immune-opioid system is effective not just for inflammatory pain but also for nerve injury pain.

Key Numbers

How They Did This

research study.

Why This Research Matters

Relevant for peptide research.

The Bigger Picture

Advances peptide research.

What This Study Doesn't Tell Us

See abstract.

Questions This Raises

  • ?Further research needed.

Trust & Context

Key Stat:
Key finding Immune cell-derived opioid peptides protected against neuropathic pain in mice, demonstrating that the peripheral immune-opioid system is effective no
Evidence Grade:
emerging evidence.
Study Age:
Published in 2009.
Original Title:
Immune cell-derived opioids protect against neuropathic pain in mice.
Published In:
The Journal of clinical investigation, 119(2), 278-86 (2009)
Database ID:
RPEP-01510

Evidence Hierarchy

Meta-Analysis / Systematic Review
Randomized Controlled Trial
Cohort / Case-Control
Cross-Sectional / ObservationalSnapshot without intervening
This study
Case Report / Animal Study
What do these levels mean? →

Frequently Asked Questions

What was studied?

Immune Cells Release Opioid Peptides That Protect Against Nerve Pain

What was found?

Immune cell-derived opioid peptides protected against neuropathic pain in mice, demonstrating that the peripheral immune-opioid system is effective not just for inflammatory pain but also for nerve injury pain.

Read More on RethinkPeptides

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Cite This Study

RPEP-01510·https://rethinkpeptides.com/research/RPEP-01510

APA

Labuz, Dominika; Schmidt, Yvonne; Schreiter, Anja; Rittner, Heike L; Mousa, Shaaban A; Machelska, Halina. (2009). Immune cell-derived opioids protect against neuropathic pain in mice.. The Journal of clinical investigation, 119(2), 278-86. https://doi.org/10.1172/JCI36246

MLA

Labuz, Dominika, et al. "Immune cell-derived opioids protect against neuropathic pain in mice.." The Journal of clinical investigation, 2009. https://doi.org/10.1172/JCI36246

RethinkPeptides

RethinkPeptides Research Database. "Immune cell-derived opioids protect against neuropathic pain..." RPEP-01510. Retrieved from https://rethinkpeptides.com/research/labuz-2009-immune-cellderived-opioids-protect

Access the Original Study

Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.

This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.