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Immune Cells Release Opioid Peptides That Protect Against Nerve Pain

evidence
The takeaway

Immune cell-derived opioid peptides protected against neuropathic pain in mice, demonstrating that the peripheral immune-opioid system is effective not just for inflammatory pain but also for nerve injury pain.

Key finding

Immune cell-derived opioid peptides protected against neuropathic pain in mice, demonstrating that the peripheral immune-opioid system is effective no

What the researchers found

Immune cell-derived opioid peptides protected against neuropathic pain in mice, demonstrating that the peripheral immune-opioid system is effective not just for inflammatory pain but also for nerve injury pain.

Why it matters

Relevant for peptide research.

How the study worked

research study.

What this study cannot tell us

See abstract.

How to read the evidence

emerging evidence.

When this study was published

Published in 2009.

The bigger picture

Advances peptide research.

Questions still open

  • Further research needed.

Common questions

What was studied?
Immune Cells Release Opioid Peptides That Protect Against Nerve Pain
What was found?
Immune cell-derived opioid peptides protected against neuropathic pain in mice, demonstrating that the peripheral immune-opioid system is effective not just for inflammatory pain but also for nerve injury pain.

Read the original research

Immune cell-derived opioids protect against neuropathic pain in mice.

The Journal of clinical investigation, 119(2), 278-86

Citation

Labuz, Dominika; Schmidt, Yvonne; Schreiter, Anja; Rittner, Heike L; Mousa, Shaaban A; Machelska, Halina. (2009). Immune cell-derived opioids protect against neuropathic pain in mice.. The Journal of clinical investigation, 119(2), 278-86. https://doi.org/10.1172/JCI36246