All-atom computational modeling revealed how hydrocarbon staples stabilize alpha-helical conformation in peptides, providing the molecular design rules for creating stable stapled peptide drugs.
Key findingAll-atom computational modeling revealed how hydrocarbon staples stabilize alpha-helical conformation in peptides, providing the molecular design rule
What the researchers found
All-atom computational modeling revealed how hydrocarbon staples stabilize alpha-helical conformation in peptides, providing the molecular design rules for creating stable stapled peptide drugs.
Why it matters
Relevant for peptide research.
How the study worked
research study.
What this study cannot tell us
See abstract.
How to read the evidence
emerging evidence.
When this study was published
Published in 2009.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
Common questions
What was studied?
What was found?
Read the original research
All-atom model for stabilization of alpha-helical structure in peptides by hydrocarbon staples.
Journal of the American Chemical Society, 131(13), 4622-7
Citation
Kutchukian, Peter S; Yang, Jae Shick; Verdine, Gregory L; Shakhnovich, Eugene I. (2009). All-atom model for stabilization of alpha-helical structure in peptides by hydrocarbon staples.. Journal of the American Chemical Society, 131(13), 4622-7. https://doi.org/10.1021/ja805037p