Apelin Is Essential for Heart Contractility: Apelin Knockout Mice Have Weak Hearts
Apelin gene-deficient mice developed impaired cardiac contractility with aging and pressure overload, proving apelin is essential for normal heart function and a potential therapeutic target for heart failure.
Quick Facts
What This Study Found
Apelin knockout mice showed impaired cardiac contractility that worsened with aging and pressure overload, definitively establishing apelin as an essential cardiac peptide and a therapeutic target for heart failure and age-related cardiac decline.
Key Numbers
How They Did This
animal-study study on neuropeptides, cardiovascular.
Why This Research Matters
Relevant for neuropeptides, cardiovascular.
The Bigger Picture
Advances peptide research.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding Apelin knockout mice showed impaired cardiac contractility that worsened with aging and pressure overload, definitively establishing apelin as an esse
- Evidence Grade:
- moderate evidence.
- Study Age:
- Published in 2007.
- Original Title:
- Impaired heart contractility in Apelin gene-deficient mice associated with aging and pressure overload.
- Published In:
- Circulation research, 101(4), e32-42 (2007)
- Authors:
- Kuba, Keiji, Zhang, Liyong, Imai, Yumiko, Arab, Sara, Chen, Manyin, Maekawa, Yuichiro, Leschnik, Michael, Leibbrandt, Andreas, Markovic, Mato, Schwaighofer, Julia, Beetz, Nadine, Musialek, Renata, Neely, G Greg, Komnenovic, Vukoslav, Kolm, Ursula, Metzler, Bernhard, Ricci, Romeo, Hara, Hiromitsu, Meixner, Arabella, Nghiem, Mai, Chen, Xin, Dawood, Fayez, Wong, Kit Man, Sarao, Renu, Cukerman, Eva, Kimura, Akinori, Hein, Lutz, Thalhammer, Johann, Liu, Peter P, Penninger, Josef M
- Database ID:
- RPEP-01251
Evidence Hierarchy
Tests effects in animals (usually mice or rats), not humans.
What do these levels mean? →Frequently Asked Questions
What was studied?
Apelin Is Essential for Heart Contractility: Apelin Knockout Mice Have Weak Hearts
What was found?
Apelin gene-deficient mice developed impaired cardiac contractility with aging and pressure overload, proving apelin is essential for normal heart function and a potential therapeutic target for heart failure.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-01251APA
Kuba, Keiji; Zhang, Liyong; Imai, Yumiko; Arab, Sara; Chen, Manyin; Maekawa, Yuichiro; Leschnik, Michael; Leibbrandt, Andreas; Markovic, Mato; Schwaighofer, Julia; Beetz, Nadine; Musialek, Renata; Neely, G Greg; Komnenovic, Vukoslav; Kolm, Ursula; Metzler, Bernhard; Ricci, Romeo; Hara, Hiromitsu; Meixner, Arabella; Nghiem, Mai; Chen, Xin; Dawood, Fayez; Wong, Kit Man; Sarao, Renu; Cukerman, Eva; Kimura, Akinori; Hein, Lutz; Thalhammer, Johann; Liu, Peter P; Penninger, Josef M. (2007). Impaired heart contractility in Apelin gene-deficient mice associated with aging and pressure overload.. Circulation research, 101(4), e32-42.
MLA
Kuba, Keiji, et al. "Impaired heart contractility in Apelin gene-deficient mice associated with aging and pressure overload.." Circulation research, 2007.
RethinkPeptides
RethinkPeptides Research Database. "Impaired heart contractility in Apelin gene-deficient mice a..." RPEP-01251. Retrieved from https://rethinkpeptides.com/research/kuba-2007-impaired-heart-contractility-in
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.