Chronic Social Stress Changes Brain CRF Levels: The Neural Basis of Stress-Induced Anxiety
Chronic psychosocial stress altered CRF levels in the paraventricular nucleus and central amygdala of rats, with changes correlating with anxiety-like behavior — mapping the neural basis of stress-induced anxiety disorders.
Quick Facts
What This Study Found
Chronic psychosocial stress produced CRF alterations in the PVN and central amygdala correlating with increased anxiety-like behavior, mapping how chronic social stress reprograms the brain's CRF stress system to produce persistent anxiety.
Key Numbers
How They Did This
animal-study study.
Why This Research Matters
Relevant for neuropeptides, anxiety-mood.
The Bigger Picture
Advances peptide research.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding Chronic psychosocial stress produced CRF alterations in the PVN and central amygdala correlating with increased anxiety-like behavior, mapping how chr
- Evidence Grade:
- preliminary evidence.
- Study Age:
- Published in 2008.
- Original Title:
- Chronic psychosocial stress affects corticotropin-releasing factor in the paraventricular nucleus and central extended amygdala as well as urocortin 1 in the non-preganglionic Edinger-Westphal nucleus of the tree shrew.
- Published In:
- Psychoneuroendocrinology, 33(6), 741-54 (2008)
- Authors:
- Kozicz, T, Bordewin, L A P, Czéh, B, Fuchs, E, Roubos, E W
- Database ID:
- RPEP-01368
Evidence Hierarchy
Tests effects in animals (usually mice or rats), not humans.
What do these levels mean? →Frequently Asked Questions
What was studied?
Chronic Social Stress Changes Brain CRF Levels: The Neural Basis of Stress-Induced Anxiety
What was found?
Chronic psychosocial stress altered CRF levels in the paraventricular nucleus and central amygdala of rats, with changes correlating with anxiety-like behavior — mapping the neural basis of stress-induced anxiety disorders.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-01368APA
Kozicz, T; Bordewin, L A P; Czéh, B; Fuchs, E; Roubos, E W. (2008). Chronic psychosocial stress affects corticotropin-releasing factor in the paraventricular nucleus and central extended amygdala as well as urocortin 1 in the non-preganglionic Edinger-Westphal nucleus of the tree shrew.. Psychoneuroendocrinology, 33(6), 741-54. https://doi.org/10.1016/j.psyneuen.2008.02.012
MLA
Kozicz, T, et al. "Chronic psychosocial stress affects corticotropin-releasing factor in the paraventricular nucleus and central extended amygdala as well as urocortin 1 in the non-preganglionic Edinger-Westphal nucleus of the tree shrew.." Psychoneuroendocrinology, 2008. https://doi.org/10.1016/j.psyneuen.2008.02.012
RethinkPeptides
RethinkPeptides Research Database. "Chronic psychosocial stress affects corticotropin-releasing ..." RPEP-01368. Retrieved from https://rethinkpeptides.com/research/kozicz-2008-chronic-psychosocial-stress-affects
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.