Chronic psychosocial stress altered CRF levels in the paraventricular nucleus and central amygdala of rats, with changes correlating with anxiety-like behavior — mapping the neural basis of stress-induced anxiety disorders.
Key findingChronic psychosocial stress produced CRF alterations in the PVN and central amygdala correlating with increased anxiety-like behavior, mapping how chr
What the researchers found
Chronic psychosocial stress produced CRF alterations in the PVN and central amygdala correlating with increased anxiety-like behavior, mapping how chronic social stress reprograms the brain's CRF stress system to produce persistent anxiety.
Why it matters
Relevant for neuropeptides, anxiety-mood.
How the study worked
animal-study study.
What this study cannot tell us
See abstract.
How to read the evidence
preliminary evidence.
When this study was published
Published in 2008.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Chronic psychosocial stress affects corticotropin-releasing factor in the paraventricular nucleus and central extended amygdala as well as urocortin 1 in the non-preganglionic Edinger-Westphal nucleus of the tree shrew.
Psychoneuroendocrinology, 33(6), 741-54
Citation
Kozicz, T; Bordewin, L A P; Czéh, B; Fuchs, E; Roubos, E W. (2008). Chronic psychosocial stress affects corticotropin-releasing factor in the paraventricular nucleus and central extended amygdala as well as urocortin 1 in the non-preganglionic Edinger-Westphal nucleus of the tree shrew.. Psychoneuroendocrinology, 33(6), 741-54. https://doi.org/10.1016/j.psyneuen.2008.02.012