Ghrelin: A Hormone With Multiple Functions Across Every Body System

Ghrelin's confirmed functions now include GH release, appetite stimulation, fat promotion, cardiovascular protection, immune modulation, gastric motility, and reproductive regulation — operating through widespread GHS-R distribution.

Korbonits, Márta et al.·Frontiers in neuroendocrinology·2004·Moderate EvidenceReview
RPEP-00936ReviewModerate Evidence2004RETHINKTHC RESEARCH DATABASErethinkthc.com/research

Quick Facts

Study Type
Review
Evidence
Moderate Evidence
Sample
Not reported

What This Study Found

Ghrelin demonstrates validated multi-system functions: GH release, appetite/adiposity control, cardiovascular protection, immune modulation, gastric motility regulation, and reproductive function — through GHS-R and non-GHS-R pathways in virtually every organ system.

Key Numbers

How They Did This

review study examining ghrp and hormone-optimization.

Why This Research Matters

Advances understanding of ghrp, hormone-optimization, cardiovascular, weight-loss, immune-function.

The Bigger Picture

Contributes to peptide research with clinical implications.

What This Study Doesn't Tell Us

Study-specific limitations; see abstract.

Questions This Raises

  • ?Further research needed.
  • ?Clinical translation potential to evaluate.

Trust & Context

Key Stat:
Key finding Ghrelin demonstrates validated multi-system functions: GH release, appetite/adiposity control, cardiovascular protection, immune modulation, gastric m
Evidence Grade:
moderate evidence from review study.
Study Age:
Published in 2004.
Original Title:
Ghrelin--a hormone with multiple functions.
Published In:
Frontiers in neuroendocrinology, 25(1), 27-68 (2004)
Database ID:
RPEP-00936

Evidence Hierarchy

Meta-Analysis / Systematic Review
Randomized Controlled Trial
Cohort / Case-Control
Cross-Sectional / ObservationalSnapshot without intervening
This study
Case Report / Animal Study

Summarizes existing research on a topic.

What do these levels mean? →

Frequently Asked Questions

What was studied?

Ghrelin: A Hormone With Multiple Functions Across Every Body System

What was found?

Ghrelin's confirmed functions now include GH release, appetite stimulation, fat promotion, cardiovascular protection, immune modulation, gastric motility, and reproductive regulation — operating through widespread GHS-R distribution.

Read More on RethinkPeptides

Cite This Study

RPEP-00936·https://rethinkpeptides.com/research/RPEP-00936

APA

Korbonits, Márta; Goldstone, Anthony P; Gueorguiev, Maria; Grossman, Ashley B. (2004). Ghrelin--a hormone with multiple functions.. Frontiers in neuroendocrinology, 25(1), 27-68.

MLA

Korbonits, Márta, et al. "Ghrelin--a hormone with multiple functions.." Frontiers in neuroendocrinology, 2004.

RethinkPeptides

RethinkPeptides Research Database. "Ghrelin--a hormone with multiple functions." RPEP-00936. Retrieved from https://rethinkpeptides.com/research/korbonits-2004-ghrelina-hormone-with-multiple

Access the Original Study

Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.

This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.