Redesigning Daptomycin: Chemical-Enzymatic Hybrid Approach to New Cyclic Lipopeptide Antibiotics
Chemoenzymatic modification of daptomycin's lipopeptide structure created hybrid antibiotics with novel activity profiles, revealing structure-activity relationships for this clinically important cyclic peptide antibiotic class.
Quick Facts
What This Study Found
Chemoenzymatic design of daptomycin-related acidic lipopeptides created hybrid antibiotics with modified activity profiles, revealing SAR rules for the daptomycin macrocyclic core and advancing next-generation cyclic lipopeptide antibiotic design.
Key Numbers
How They Did This
in-vitro study on cyclic-peptides, antimicrobial-peptides.
Why This Research Matters
Relevant for cyclic-peptides, antimicrobial-peptides, peptide-design.
The Bigger Picture
Advances peptide research.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding Chemoenzymatic design of daptomycin-related acidic lipopeptides created hybrid antibiotics with modified activity profiles, revealing SAR rules for th
- Evidence Grade:
- preliminary evidence.
- Study Age:
- Published in 2006.
- Original Title:
- Chemoenzymatic design of acidic lipopeptide hybrids: new insights into the structure-activity relationship of daptomycin and A54145.
- Published In:
- Biochemistry, 45(35), 10474-81 (2006)
- Database ID:
- RPEP-01154
Evidence Hierarchy
Frequently Asked Questions
What was studied?
Redesigning Daptomycin: Chemical-Enzymatic Hybrid Approach to New Cyclic Lipopeptide Antibiotics
What was found?
Chemoenzymatic modification of daptomycin's lipopeptide structure created hybrid antibiotics with novel activity profiles, revealing structure-activity relationships for this clinically important cyclic peptide antibiotic class.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-01154APA
Kopp, Florian; Grünewald, Jan; Mahlert, Christoph; Marahiel, Mohamed A. (2006). Chemoenzymatic design of acidic lipopeptide hybrids: new insights into the structure-activity relationship of daptomycin and A54145.. Biochemistry, 45(35), 10474-81.
MLA
Kopp, Florian, et al. "Chemoenzymatic design of acidic lipopeptide hybrids: new insights into the structure-activity relationship of daptomycin and A54145.." Biochemistry, 2006.
RethinkPeptides
RethinkPeptides Research Database. "Chemoenzymatic design of acidic lipopeptide hybrids: new ins..." RPEP-01154. Retrieved from https://rethinkpeptides.com/research/kopp-2006-chemoenzymatic-design-of-acidic
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.