Selank Inhibits Ethanol-Induced Hyperlocomotion and Manifestation of Behavioral Sensitization in DBA/2 Mice.
Quick Facts
What This Study Found
Selank administered intraperitoneally at 0.3 mg/kg prevented ethanol-induced hyperlocomotion and blocked the manifestation of motor sensitization in male DBA/2 mice, indicating modulation of ethanol's motivational effects.
Key Numbers
How They Did This
Male DBA/2 mice were given intraperitoneal injections of Selank, naloxone, or Afobazole before ethanol administration. Locomotor activity and behavioral sensitization were measured to assess the effects of these compounds on ethanol-induced stimulation.
Why This Research Matters
Understanding how Selank modulates alcohol-induced behaviors could help develop new treatments for alcohol-related disorders and expand knowledge on peptide-based anxiolytics.
What This Study Doesn't Tell Us
The study was conducted only in male DBA/2 mice, limiting generalizability to other strains, species, or females. The evidence strength and study type were not specified.
Trust & Context
- Original Title:
- Selank Inhibits Ethanol-Induced Hyperlocomotion and Manifestation of Behavioral Sensitization in DBA/2 Mice.
- Published In:
- Bulletin of experimental biology and medicine, 162(1), 56-59 (2016)
- Authors:
- Kolik, L G(2), Nadorova, A V(2), Seredenin, S B
- Database ID:
- RPEP-02996
Evidence Hierarchy
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Cite This Study
https://rethinkpeptides.com/research/RPEP-02996APA
Kolik, L G; Nadorova, A V; Seredenin, S B. (2016). Selank Inhibits Ethanol-Induced Hyperlocomotion and Manifestation of Behavioral Sensitization in DBA/2 Mice.. Bulletin of experimental biology and medicine, 162(1), 56-59.
MLA
Kolik, L G, et al. "Selank Inhibits Ethanol-Induced Hyperlocomotion and Manifestation of Behavioral Sensitization in DBA/2 Mice.." Bulletin of experimental biology and medicine, 2016.
RethinkPeptides
RethinkPeptides Research Database. "Selank Inhibits Ethanol-Induced Hyperlocomotion and Manifest..." RPEP-02996. Retrieved from https://rethinkpeptides.com/research/kolik-2016-selank-inhibits-ethanolinduced-hyperlocomotion
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.