Duodenal enteroendocrine cells released endogenous opioid peptides (beta-endorphin) in response to nutrients through TRPM5 taste channels — the gut has its own opioid signaling triggered by food tasting at the intestinal level.
Key findingDuodenal enteroendocrine cells released endogenous opioid peptides (beta-endorphin) in response to nutrients through TRPM5 taste channels — the gut ha
What the researchers found
Duodenal enteroendocrine cells released endogenous opioid peptides (beta-endorphin) in response to nutrients through TRPM5 taste channels — the gut has its own opioid signaling triggered by food tasting at the intestinal level.
Why it matters
Relevant for peptide research.
How the study worked
research study.
What this study cannot tell us
See abstract.
How to read the evidence
emerging evidence.
When this study was published
Published in 2009.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
Common questions
What was studied?
What was found?
Read the original research
Release of endogenous opioids from duodenal enteroendocrine cells requires Trpm5.
Gastroenterology, 137(2), 598-606, 606.e1-2
Citation
Kokrashvili, Zaza; Rodriguez, Deniliz; Yevshayeva, Valeriya; Zhou, Hang; Margolskee, Robert F; Mosinger, Bedrich. (2009). Release of endogenous opioids from duodenal enteroendocrine cells requires Trpm5.. Gastroenterology, 137(2), 598-606, 606.e1-2. https://doi.org/10.1053/j.gastro.2009.02.070