This review covers ghrelin's molecular structure (28 amino acids, octanoylated Ser3), receptor pharmacology (GHS-R1a), tissue distribution, and multi-system functions — the complete structural-functional reference for this peptide.
Key findingGhrelin's complete structural-functional profile: 28 amino acids with essential octanoyl modification on Ser3, GHS-R1a receptor activation, widespread
What the researchers found
Ghrelin's complete structural-functional profile: 28 amino acids with essential octanoyl modification on Ser3, GHS-R1a receptor activation, widespread tissue expression, and validated functions in GH release, appetite, energy homeostasis, and cardiovascular protection.
Why it matters
Relevant for neuropeptides, hormone-optimization, weight-loss.
How the study worked
review study.
What this study cannot tell us
See abstract.
How to read the evidence
moderate evidence.
When this study was published
Published in 2008.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Structure and function of ghrelin.
Results and problems in cell differentiation, 46, 89-115
Citation
Kojima, Masayasu; Kangawa, Kenji. (2008). Structure and function of ghrelin.. Results and problems in cell differentiation, 46, 89-115. https://doi.org/10.1007/400_2007_049