Structure and Function of Ghrelin: The Complete Molecular Biology of the Hunger Hormone
This review covers ghrelin's molecular structure (28 amino acids, octanoylated Ser3), receptor pharmacology (GHS-R1a), tissue distribution, and multi-system functions — the complete structural-functional reference for this peptide.
Quick Facts
What This Study Found
Ghrelin's complete structural-functional profile: 28 amino acids with essential octanoyl modification on Ser3, GHS-R1a receptor activation, widespread tissue expression, and validated functions in GH release, appetite, energy homeostasis, and cardiovascular protection.
Key Numbers
How They Did This
review study.
Why This Research Matters
Relevant for neuropeptides, hormone-optimization, weight-loss.
The Bigger Picture
Advances peptide research.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding Ghrelin's complete structural-functional profile: 28 amino acids with essential octanoyl modification on Ser3, GHS-R1a receptor activation, widespread
- Evidence Grade:
- moderate evidence.
- Study Age:
- Published in 2008.
- Original Title:
- Structure and function of ghrelin.
- Published In:
- Results and problems in cell differentiation, 46, 89-115 (2008)
- Authors:
- Kojima, Masayasu(4), Kangawa, Kenji(10)
- Database ID:
- RPEP-01367
Evidence Hierarchy
Summarizes existing research on a topic.
What do these levels mean? →Frequently Asked Questions
What was studied?
Structure and Function of Ghrelin: The Complete Molecular Biology of the Hunger Hormone
What was found?
This review covers ghrelin's molecular structure (28 amino acids, octanoylated Ser3), receptor pharmacology (GHS-R1a), tissue distribution, and multi-system functions — the complete structural-functional reference for this peptide.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-01367APA
Kojima, Masayasu; Kangawa, Kenji. (2008). Structure and function of ghrelin.. Results and problems in cell differentiation, 46, 89-115. https://doi.org/10.1007/400_2007_049
MLA
Kojima, Masayasu, et al. "Structure and function of ghrelin.." Results and problems in cell differentiation, 2008. https://doi.org/10.1007/400_2007_049
RethinkPeptides
RethinkPeptides Research Database. "Structure and function of ghrelin." RPEP-01367. Retrieved from https://rethinkpeptides.com/research/kojima-2008-structure-and-function-of
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.