The Female Sexual Response: Current Models, Neurobiological Underpinnings and Agents Currently Approved or Under Investigation for the Treatment of Hypoactive Sexual Desire Disorder.
Quick Facts
What This Study Found
HSDD likely results from an imbalance between excitatory and inhibitory neurobiological pathways regulating sexual desire, involving neurotransmitters like dopamine, norepinephrine, serotonin, and oxytocin. Flibanserin is the first FDA-approved drug targeting these pathways for premenopausal women with HSDD, with other agents under investigation.
Key Numbers
How They Did This
This is a review article summarizing current models of female sexual response, neurobiological mechanisms, and available or investigational treatments for HSDD based on existing research and clinical data.
Why This Research Matters
This review highlights the complexity of female sexual desire and the neurobiological basis of HSDD, guiding development of targeted therapies that can improve women's sexual health and quality of life.
What This Study Doesn't Tell Us
The article is a review and does not present new experimental data; evidence strength and study types vary across cited research.
Trust & Context
- Original Title:
- The Female Sexual Response: Current Models, Neurobiological Underpinnings and Agents Currently Approved or Under Investigation for the Treatment of Hypoactive Sexual Desire Disorder.
- Published In:
- CNS drugs, 29(11), 915-33 (2015)
- Authors:
- Kingsberg, Sheryl A, Clayton, Anita H, Pfaus, James G
- Database ID:
- RPEP-02688
Evidence Hierarchy
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Cite This Study
https://rethinkpeptides.com/research/RPEP-02688APA
Kingsberg, Sheryl A; Clayton, Anita H; Pfaus, James G. (2015). The Female Sexual Response: Current Models, Neurobiological Underpinnings and Agents Currently Approved or Under Investigation for the Treatment of Hypoactive Sexual Desire Disorder.. CNS drugs, 29(11), 915-33. https://doi.org/10.1007/s40263-015-0288-1
MLA
Kingsberg, Sheryl A, et al. "The Female Sexual Response: Current Models, Neurobiological Underpinnings and Agents Currently Approved or Under Investigation for the Treatment of Hypoactive Sexual Desire Disorder.." CNS drugs, 2015. https://doi.org/10.1007/s40263-015-0288-1
RethinkPeptides
RethinkPeptides Research Database. "The Female Sexual Response: Current Models, Neurobiological ..." RPEP-02688. Retrieved from https://rethinkpeptides.com/research/kingsberg-2015-the-female-sexual-response
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Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.