Nicotine's Pain Relief Works Partly Through Spinal Met-Enkephalin Release
Nicotine-induced antinociception in mice involved spinal met-enkephalin release, as confirmed by intrathecal anti-met-enkephalin antibodies — another drug that works partly by triggering the body's own painkillers.
Quick Facts
What This Study Found
Nicotine antinociception involved spinal met-enkephalin release confirmed by intrathecal anti-met-enkephalin antibody blocking, extending the drug-endogenous opioid amplification mechanism to nicotine — explaining some of smoking's pain-modifying effects.
Key Numbers
How They Did This
animal-study study.
Why This Research Matters
Relevant for opioid-peptides, neuropeptides, pain.
The Bigger Picture
Advances peptide research.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding Nicotine antinociception involved spinal met-enkephalin release confirmed by intrathecal anti-met-enkephalin antibody blocking, extending the drug-end
- Evidence Grade:
- preliminary evidence.
- Study Age:
- Published in 2008.
- Original Title:
- Involvement of spinal Met-enkephalin in nicotine-induced antinociception in mice.
- Published In:
- Brain research, 1189, 70-7 (2008)
- Authors:
- Kiguchi, Norikazu, Maeda, Takehiko, Tsuruga, Mie, Yamamoto, Akihiro, Yamamoto, Chizuko, Ozaki, Masanobu, Kishioka, Shiroh
- Database ID:
- RPEP-01365
Evidence Hierarchy
Tests effects in animals (usually mice or rats), not humans.
What do these levels mean? →Frequently Asked Questions
What was studied?
Nicotine's Pain Relief Works Partly Through Spinal Met-Enkephalin Release
What was found?
Nicotine-induced antinociception in mice involved spinal met-enkephalin release, as confirmed by intrathecal anti-met-enkephalin antibodies — another drug that works partly by triggering the body's own painkillers.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-01365APA
Kiguchi, Norikazu; Maeda, Takehiko; Tsuruga, Mie; Yamamoto, Akihiro; Yamamoto, Chizuko; Ozaki, Masanobu; Kishioka, Shiroh. (2008). Involvement of spinal Met-enkephalin in nicotine-induced antinociception in mice.. Brain research, 1189, 70-7.
MLA
Kiguchi, Norikazu, et al. "Involvement of spinal Met-enkephalin in nicotine-induced antinociception in mice.." Brain research, 2008.
RethinkPeptides
RethinkPeptides Research Database. "Involvement of spinal Met-enkephalin in nicotine-induced ant..." RPEP-01365. Retrieved from https://rethinkpeptides.com/research/kiguchi-2008-involvement-of-spinal-metenkephalin
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.