Nicotine-induced antinociception in mice involved spinal met-enkephalin release, as confirmed by intrathecal anti-met-enkephalin antibodies — another drug that works partly by triggering the body's own painkillers.
Key findingNicotine antinociception involved spinal met-enkephalin release confirmed by intrathecal anti-met-enkephalin antibody blocking, extending the drug-end
What the researchers found
Nicotine antinociception involved spinal met-enkephalin release confirmed by intrathecal anti-met-enkephalin antibody blocking, extending the drug-endogenous opioid amplification mechanism to nicotine — explaining some of smoking's pain-modifying effects.
Why it matters
Relevant for opioid-peptides, neuropeptides, pain.
How the study worked
animal-study study.
What this study cannot tell us
See abstract.
How to read the evidence
preliminary evidence.
When this study was published
Published in 2008.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Involvement of spinal Met-enkephalin in nicotine-induced antinociception in mice.
Brain research, 1189, 70-7
Citation
Kiguchi, Norikazu; Maeda, Takehiko; Tsuruga, Mie; Yamamoto, Akihiro; Yamamoto, Chizuko; Ozaki, Masanobu; Kishioka, Shiroh. (2008). Involvement of spinal Met-enkephalin in nicotine-induced antinociception in mice.. Brain research, 1189, 70-7.