KPV Immobilized on Surfaces Still Blocks NF-κB: Anti-Inflammatory Peptide Coatings
Alpha-MSH analog GKPV immobilized on surfaces inhibited TNF-α-stimulated NF-κB activation in cells, demonstrating that KPV-related peptides retain anti-inflammatory activity when attached to biomaterial surfaces — enabling anti-inflammatory medical device coatings.
Quick Facts
What This Study Found
GKPV (alpha-MSH 10-13) immobilized on surfaces retained NF-κB inhibitory activity against TNF-α-stimulated inflammation in vitro, demonstrating that KPV-related peptides can function as bioactive anti-inflammatory coatings for medical devices and implants.
Key Numbers
How They Did This
in-vitro study on kpv, inflammation.
Why This Research Matters
Relevant for kpv, inflammation.
The Bigger Picture
Advances peptide research.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding GKPV (alpha-MSH 10-13) immobilized on surfaces retained NF-κB inhibitory activity against TNF-α-stimulated inflammation in vitro, demonstrating that K
- Evidence Grade:
- preliminary evidence.
- Study Age:
- Published in 2006.
- Original Title:
- Immobilized alpha-melanocyte stimulating hormone 10-13 (GKPV) inhibits tumor necrosis factor-alpha stimulated NF-kappaB activity.
- Published In:
- Peptides, 27(2), 431-7 (2006)
- Authors:
- Kelly, J M, Moir, A J G, Carlson, K, Yang, Y, MacNeil, S, Haycock, J W
- Database ID:
- RPEP-01151
Evidence Hierarchy
Frequently Asked Questions
What was studied?
KPV Immobilized on Surfaces Still Blocks NF-κB: Anti-Inflammatory Peptide Coatings
What was found?
Alpha-MSH analog GKPV immobilized on surfaces inhibited TNF-α-stimulated NF-κB activation in cells, demonstrating that KPV-related peptides retain anti-inflammatory activity when attached to biomaterial surfaces — enabling anti-inflammatory medical device coatings.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-01151APA
Kelly, J M; Moir, A J G; Carlson, K; Yang, Y; MacNeil, S; Haycock, J W. (2006). Immobilized alpha-melanocyte stimulating hormone 10-13 (GKPV) inhibits tumor necrosis factor-alpha stimulated NF-kappaB activity.. Peptides, 27(2), 431-7.
MLA
Kelly, J M, et al. "Immobilized alpha-melanocyte stimulating hormone 10-13 (GKPV) inhibits tumor necrosis factor-alpha stimulated NF-kappaB activity.." Peptides, 2006.
RethinkPeptides
RethinkPeptides Research Database. "Immobilized alpha-melanocyte stimulating hormone 10-13 (GKPV..." RPEP-01151. Retrieved from https://rethinkpeptides.com/research/kelly-2006-immobilized-alphamelanocyte-stimulating-hormone
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.