Mu, delta, and kappa opioid receptors were all detected in the guinea pig cochlea, establishing the molecular basis for opioid peptide signaling in the inner ear — relevant to hearing protection and auditory dysfunction.
Key findingAll three opioid receptor types (mu, delta, kappa) were demonstrated in the guinea pig cochlea by RT-PCR, immunohistochemistry, and autoradiography, e
What the researchers found
All three opioid receptor types (mu, delta, kappa) were demonstrated in the guinea pig cochlea by RT-PCR, immunohistochemistry, and autoradiography, establishing the complete molecular basis for opioid peptide signaling in the auditory system.
Why it matters
Relevant for opioid-peptides, neuropeptides.
How the study worked
animal-study study on opioid-peptides, neuropeptides.
What this study cannot tell us
See abstract.
How to read the evidence
preliminary evidence.
When this study was published
Published in 2006.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
The existence of opioid receptors in the cochlea of guinea pigs.
The European journal of neuroscience, 23(10), 2701-11
Citation
Jongkamonwiwat, Nopporn; Phansuwan-Pujito, Pansiri; Casalotti, Stefano O; Forge, Andrew; Dodson, Hilary; Govitrapong, Piyarat. (2006). The existence of opioid receptors in the cochlea of guinea pigs.. The European journal of neuroscience, 23(10), 2701-11.