Opioid Receptors Exist in the Inner Ear: Potential Targets for Hearing Protection
Mu, delta, and kappa opioid receptors were all detected in the guinea pig cochlea, establishing the molecular basis for opioid peptide signaling in the inner ear — relevant to hearing protection and auditory dysfunction.
Quick Facts
What This Study Found
All three opioid receptor types (mu, delta, kappa) were demonstrated in the guinea pig cochlea by RT-PCR, immunohistochemistry, and autoradiography, establishing the complete molecular basis for opioid peptide signaling in the auditory system.
Key Numbers
How They Did This
animal-study study on opioid-peptides, neuropeptides.
Why This Research Matters
Relevant for opioid-peptides, neuropeptides.
The Bigger Picture
Advances peptide research.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding All three opioid receptor types (mu, delta, kappa) were demonstrated in the guinea pig cochlea by RT-PCR, immunohistochemistry, and autoradiography, e
- Evidence Grade:
- preliminary evidence.
- Study Age:
- Published in 2006.
- Original Title:
- The existence of opioid receptors in the cochlea of guinea pigs.
- Published In:
- The European journal of neuroscience, 23(10), 2701-11 (2006)
- Authors:
- Jongkamonwiwat, Nopporn, Phansuwan-Pujito, Pansiri, Casalotti, Stefano O, Forge, Andrew, Dodson, Hilary, Govitrapong, Piyarat
- Database ID:
- RPEP-01150
Evidence Hierarchy
Tests effects in animals (usually mice or rats), not humans.
What do these levels mean? →Frequently Asked Questions
What was studied?
Opioid Receptors Exist in the Inner Ear: Potential Targets for Hearing Protection
What was found?
Mu, delta, and kappa opioid receptors were all detected in the guinea pig cochlea, establishing the molecular basis for opioid peptide signaling in the inner ear — relevant to hearing protection and auditory dysfunction.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-01150APA
Jongkamonwiwat, Nopporn; Phansuwan-Pujito, Pansiri; Casalotti, Stefano O; Forge, Andrew; Dodson, Hilary; Govitrapong, Piyarat. (2006). The existence of opioid receptors in the cochlea of guinea pigs.. The European journal of neuroscience, 23(10), 2701-11.
MLA
Jongkamonwiwat, Nopporn, et al. "The existence of opioid receptors in the cochlea of guinea pigs.." The European journal of neuroscience, 2006.
RethinkPeptides
RethinkPeptides Research Database. "The existence of opioid receptors in the cochlea of guinea p..." RPEP-01150. Retrieved from https://rethinkpeptides.com/research/jongkamonwiwat-2006-the-existence-of-opioid
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.