This record provides bibliographic details and links to the original research. An editorial study breakdown is not available.
What the researchers found
Stapled peptides and small-molecule inhibitors effectively target protein-protein interactions in key cancer-related proteins such as β-catenin, Bcl-2 family members, and Mdm2. These inhibitors provide a promising strategy to overcome resistance and improve selectivity in cancer therapy.
Why it matters
Targeting protein-protein interactions with stapled peptides could overcome limitations of traditional drugs and address previously 'undruggable' cancer targets, potentially improving treatment outcomes.
How the study worked
This is a literature review summarizing studies on stapled peptides and small molecules that inhibit protein-protein interactions in mammalian cancer targets. It surveys various protein targets and the development of inhibitors designed to disrupt their interactions.
What this study cannot tell us
As a review, it does not present new experimental data and the evidence strength and study types of included research vary. The clinical efficacy and safety of stapled peptides remain to be fully established.
Read the original research
A Review of Stapled Peptides and Small Molecules to Inhibit Protein-Protein Interactions in Cancer.
Current medicinal chemistry, 23(27), 3025-3043
Citation
Iyer, Vidhya V. (2016). A Review of Stapled Peptides and Small Molecules to Inhibit Protein-Protein Interactions in Cancer.. Current medicinal chemistry, 23(27), 3025-3043.