A Review of Stapled Peptides and Small Molecules to Inhibit Protein-Protein Interactions in Cancer.

Stapled peptides and small-molecule inhibitors effectively target protein-protein interactions in key cancer-related proteins such as β-catenin, Bcl-2 family members, and Mdm2. These inhibitors provide a promising strategy to overcome resistance and improve selectivity in cancer therapy.

This is a literature review summarizing studies on stapled peptides and small molecules that inhibit protein-protein interactions in mammalian cancer targets. It surveys various protein targets and the development of inhibitors designed to disrupt their interactions.

Targeting protein-protein interactions with stapled peptides could overcome limitations of traditional drugs and address previously 'undruggable' cancer targets, potentially improving treatment outcomes.

As a review, it does not present new experimental data and the evidence strength and study types of included research vary. The clinical efficacy and safety of stapled peptides remain to be fully established.