Mu-opioid receptor agonist and antagonist peptides showed varying permeability across Caco-2 intestinal monolayers, with some achieving meaningful transport — assessing the oral bioavailability potential of opioid peptides.
Key findingMu-opioid peptide agonists and antagonists showed variable Caco-2 monolayer permeability, with some achieving transcellular transport — assessing oral
What the researchers found
Mu-opioid peptide agonists and antagonists showed variable Caco-2 monolayer permeability, with some achieving transcellular transport — assessing oral bioavailability potential and identifying which opioid peptide structures achieve gut barrier crossing.
Why it matters
Relevant for opioid-peptides, bioactive-food-peptides, bioavailability.
How the study worked
in-vitro study.
What this study cannot tell us
See abstract.
How to read the evidence
preliminary evidence.
When this study was published
Published in 2008.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Transport of micro-opioid receptor agonists and antagonist peptides across Caco-2 monolayer.
Peptides, 29(6), 1042-7
Citation
Iwan, Małgorzata; Jarmołowska, Beata; Bielikowicz, Krzysztof; Kostyra, Elzbieta; Kostyra, Henryk; Kaczmarski, Maciej. (2008). Transport of micro-opioid receptor agonists and antagonist peptides across Caco-2 monolayer.. Peptides, 29(6), 1042-7. https://doi.org/10.1016/j.peptides.2008.01.018