How Well Do Opioid Peptides Cross the Gut Barrier? Transport Across Intestinal Cell Monolayers
Mu-opioid receptor agonist and antagonist peptides showed varying permeability across Caco-2 intestinal monolayers, with some achieving meaningful transport — assessing the oral bioavailability potential of opioid peptides.
Quick Facts
What This Study Found
Mu-opioid peptide agonists and antagonists showed variable Caco-2 monolayer permeability, with some achieving transcellular transport — assessing oral bioavailability potential and identifying which opioid peptide structures achieve gut barrier crossing.
Key Numbers
How They Did This
in-vitro study.
Why This Research Matters
Relevant for opioid-peptides, bioactive-food-peptides, bioavailability.
The Bigger Picture
Advances peptide research.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding Mu-opioid peptide agonists and antagonists showed variable Caco-2 monolayer permeability, with some achieving transcellular transport — assessing oral
- Evidence Grade:
- preliminary evidence.
- Study Age:
- Published in 2008.
- Original Title:
- Transport of micro-opioid receptor agonists and antagonist peptides across Caco-2 monolayer.
- Published In:
- Peptides, 29(6), 1042-7 (2008)
- Authors:
- Iwan, Małgorzata, Jarmołowska, Beata, Bielikowicz, Krzysztof, Kostyra, Elzbieta, Kostyra, Henryk, Kaczmarski, Maciej
- Database ID:
- RPEP-01358
Evidence Hierarchy
Frequently Asked Questions
What was studied?
How Well Do Opioid Peptides Cross the Gut Barrier? Transport Across Intestinal Cell Monolayers
What was found?
Mu-opioid receptor agonist and antagonist peptides showed varying permeability across Caco-2 intestinal monolayers, with some achieving meaningful transport — assessing the oral bioavailability potential of opioid peptides.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-01358APA
Iwan, Małgorzata; Jarmołowska, Beata; Bielikowicz, Krzysztof; Kostyra, Elzbieta; Kostyra, Henryk; Kaczmarski, Maciej. (2008). Transport of micro-opioid receptor agonists and antagonist peptides across Caco-2 monolayer.. Peptides, 29(6), 1042-7. https://doi.org/10.1016/j.peptides.2008.01.018
MLA
Iwan, Małgorzata, et al. "Transport of micro-opioid receptor agonists and antagonist peptides across Caco-2 monolayer.." Peptides, 2008. https://doi.org/10.1016/j.peptides.2008.01.018
RethinkPeptides
RethinkPeptides Research Database. "Transport of micro-opioid receptor agonists and antagonist p..." RPEP-01358. Retrieved from https://rethinkpeptides.com/research/iwan-2008-transport-of-microopioid-receptor
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.