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Study breakdown

BPC-157 Protects Against Paracetamol Overdose Brain Damage and Seizures in Rats

evidence
The takeaway

BPC-157 counteracted high-dose paracetamol-induced brain damage, seizures, and hepatotoxicity in rats — adding acetaminophen overdose protection to its expanding organ protection profile.

Key finding

BPC-157 counteracted high-dose paracetamol-induced brain damage, seizures, and hepatotoxicity in rats — adding acetaminophen overdose protection to it

What the researchers found

BPC-157 counteracted high-dose paracetamol-induced brain damage, seizures, and hepatotoxicity in rats — adding acetaminophen overdose protection to its expanding organ protection profile.

Why it matters

Relevant for peptide research.

How the study worked

research study.

What this study cannot tell us

See abstract.

How to read the evidence

emerging evidence.

When this study was published

Published in 2010.

The bigger picture

Advances peptide research.

Questions still open

  • Further research needed.

Common questions

What was studied?
BPC-157 Protects Against Paracetamol Overdose Brain Damage and Seizures in Rats
What was found?
BPC-157 counteracted high-dose paracetamol-induced brain damage, seizures, and hepatotoxicity in rats — adding acetaminophen overdose protection to its expanding organ protection profile.

Read the original research

High hepatotoxic dose of paracetamol produces generalized convulsions and brain damage in rats. A counteraction with the stable gastric pentadecapeptide BPC 157 (PL 14736).

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 61(2), 241-50

Citation

Ilic, S; Drmic, D; Zarkovic, K; Kolenc, D; Coric, M; Brcic, L; Klicek, R; Radic, B; Sever, M; Djuzel, V; Ivica, M; Boban Blagaic, A; Zoricic, Z; Anic, T; Zoricic, I; Djidic, S; Romic, Z; Seiwerth, S; Sikiric, P. (2010). High hepatotoxic dose of paracetamol produces generalized convulsions and brain damage in rats. A counteraction with the stable gastric pentadecapeptide BPC 157 (PL 14736).. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 61(2), 241-50.