Heart Cells Make Their Own Ghrelin: A Local Cardiac Ghrelin System
Cardiomyocytes synthesize and secrete ghrelin with functional GHS-R expression, establishing a local cardiac ghrelin autocrine/paracrine system that may contribute to cardiac protection and remodeling.
Quick Facts
What This Study Found
Cardiomyocytes expressed ghrelin mRNA and protein, secreted ghrelin into culture medium, and expressed functional GHS-R — establishing an autocrine/paracrine cardiac ghrelin system for local cardiac regulation and protection.
Key Numbers
How They Did This
in-vitro study examining ghrp and cardiovascular.
Why This Research Matters
Advances understanding of ghrp, cardiovascular, receptor-signaling with translational implications.
The Bigger Picture
Contributes to the growing body of peptide research with implications for clinical development and therapeutic applications.
What This Study Doesn't Tell Us
Study-specific limitations apply; see abstract for details.
Questions This Raises
- ?Further research needed to confirm and extend these findings.
- ?Clinical translation and safety need evaluation.
- ?Optimal dosing and delivery require characterization.
Trust & Context
- Key Stat:
- Key finding Cardiomyocytes expressed ghrelin mRNA and protein, secreted ghrelin into culture medium, and expressed functional GHS-R — establishing an autocrine/pa
- Evidence Grade:
- preliminary evidence from in-vitro study design.
- Study Age:
- Published in 2004.
- Original Title:
- Growth hormone releasing peptide (ghrelin) is synthesized and secreted by cardiomyocytes.
- Published In:
- Cardiovascular research, 62(3), 481-8 (2004)
- Authors:
- Iglesias, María J, Piñeiro, Roberto, Blanco, Montserrat, Gallego, Rosalía, Diéguez, Carlos, Gualillo, Oreste, González-Juanatey, José R, Lago, Francisca
- Database ID:
- RPEP-00928
Evidence Hierarchy
Frequently Asked Questions
What was the main focus of this study?
Heart Cells Make Their Own Ghrelin: A Local Cardiac Ghrelin System
What was discovered?
Cardiomyocytes synthesize and secrete ghrelin with functional GHS-R expression, establishing a local cardiac ghrelin autocrine/paracrine system that may contribute to cardiac protection and remodeling.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-00928APA
Iglesias, María J; Piñeiro, Roberto; Blanco, Montserrat; Gallego, Rosalía; Diéguez, Carlos; Gualillo, Oreste; González-Juanatey, José R; Lago, Francisca. (2004). Growth hormone releasing peptide (ghrelin) is synthesized and secreted by cardiomyocytes.. Cardiovascular research, 62(3), 481-8.
MLA
Iglesias, María J, et al. "Growth hormone releasing peptide (ghrelin) is synthesized and secreted by cardiomyocytes.." Cardiovascular research, 2004.
RethinkPeptides
RethinkPeptides Research Database. "Growth hormone releasing peptide (ghrelin) is synthesized an..." RPEP-00928. Retrieved from https://rethinkpeptides.com/research/iglesias-2004-growth-hormone-releasing-peptide
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.