Constipation Caused by Anti-calcitonin Gene-Related Peptide Migraine Therapeutics Explained by Antagonism of Calcitonin Gene-Related Peptide's Motor-Stimulating and Prosecretory Function in the Intestine.
Quick Facts
What This Study Found
Constipation from anti-CGRP migraine therapeutics results from blocking CGRP's physiological role in maintaining intestinal peristalsis, ion/water secretion, and transit through both extrinsic and enteric nerve pathways.
Key Numbers
>50% constipation rate; CGRP drives peristalsis; CGRP drives secretion; CGRP accelerates transit; causes diarrhea exogenously
How They Did This
Narrative review of CGRP's pharmacological actions in the digestive tract, including enteric nervous system function, peristalsis, secretion, and transit studies in animals and humans.
Why This Research Matters
Over 50% of patients on anti-CGRP drugs experience constipation. Understanding why helps clinicians manage this side effect and set proper expectations for patients starting these medications.
What This Study Doesn't Tell Us
Narrative review with no original data. The >50% constipation rate is from real-world surveys, not randomized trials. Individual variation in constipation severity is not well characterized. Management strategies for the constipation are not reviewed.
Trust & Context
- Original Title:
- Constipation Caused by Anti-calcitonin Gene-Related Peptide Migraine Therapeutics Explained by Antagonism of Calcitonin Gene-Related Peptide's Motor-Stimulating and Prosecretory Function in the Intestine.
- Published In:
- Frontiers in physiology, 12, 820006 (2021)
- Authors:
- Holzer, Peter(3), Holzer-Petsche, Ulrike
- Database ID:
- RPEP-05448
Evidence Hierarchy
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Cite This Study
https://rethinkpeptides.com/research/RPEP-05448APA
Holzer, Peter; Holzer-Petsche, Ulrike. (2021). Constipation Caused by Anti-calcitonin Gene-Related Peptide Migraine Therapeutics Explained by Antagonism of Calcitonin Gene-Related Peptide's Motor-Stimulating and Prosecretory Function in the Intestine.. Frontiers in physiology, 12, 820006. https://doi.org/10.3389/fphys.2021.820006
MLA
Holzer, Peter, et al. "Constipation Caused by Anti-calcitonin Gene-Related Peptide Migraine Therapeutics Explained by Antagonism of Calcitonin Gene-Related Peptide's Motor-Stimulating and Prosecretory Function in the Intestine.." Frontiers in physiology, 2021. https://doi.org/10.3389/fphys.2021.820006
RethinkPeptides
RethinkPeptides Research Database. "Constipation Caused by Anti-calcitonin Gene-Related Peptide ..." RPEP-05448. Retrieved from https://rethinkpeptides.com/research/holzer-2021-constipation-caused-by-anticalcitonin
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.