The endogenous ghrelin, synthetic agonists, and ago-allosteric modulators all bind overlapping sites on the ghrelin receptor — they compete for the same binding pocket rather than using separate allosteric sites.
Key findingThe endogenous ghrelin, synthetic agonists, and ago-allosteric modulators all bind overlapping sites on the ghrelin receptor — they compete for the sa
What the researchers found
The endogenous ghrelin, synthetic agonists, and ago-allosteric modulators all bind overlapping sites on the ghrelin receptor — they compete for the same binding pocket rather than using separate allosteric sites.
Why it matters
Relevant for peptide research.
How the study worked
research study.
What this study cannot tell us
See abstract.
How to read the evidence
emerging evidence.
When this study was published
Published in 2009.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
Common questions
What was studied?
What was found?
Read the original research
Overlapping binding site for the endogenous agonist, small-molecule agonists, and ago-allosteric modulators on the ghrelin receptor.
Molecular pharmacology, 75(1), 44-59
Citation
Holst, Birgitte; Frimurer, Thomas M; Mokrosinski, Jacek; Halkjaer, Tine; Cullberg, Karina B; Underwood, Christina R; Schwartz, Thue W. (2009). Overlapping binding site for the endogenous agonist, small-molecule agonists, and ago-allosteric modulators on the ghrelin receptor.. Molecular pharmacology, 75(1), 44-59. https://doi.org/10.1124/mol.108.049189