Ghrelin, Small Molecule Agonists, and Modulators All Share the Same Receptor Binding Site
The endogenous ghrelin, synthetic agonists, and ago-allosteric modulators all bind overlapping sites on the ghrelin receptor — they compete for the same binding pocket rather than using separate allosteric sites.
Quick Facts
What This Study Found
The endogenous ghrelin, synthetic agonists, and ago-allosteric modulators all bind overlapping sites on the ghrelin receptor — they compete for the same binding pocket rather than using separate allosteric sites.
Key Numbers
How They Did This
research study.
Why This Research Matters
Relevant for peptide research.
The Bigger Picture
Advances peptide research.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
Trust & Context
- Key Stat:
- Key finding The endogenous ghrelin, synthetic agonists, and ago-allosteric modulators all bind overlapping sites on the ghrelin receptor — they compete for the sa
- Evidence Grade:
- emerging evidence.
- Study Age:
- Published in 2009.
- Original Title:
- Overlapping binding site for the endogenous agonist, small-molecule agonists, and ago-allosteric modulators on the ghrelin receptor.
- Published In:
- Molecular pharmacology, 75(1), 44-59 (2009)
- Authors:
- Holst, Birgitte(6), Frimurer, Thomas M(3), Mokrosinski, Jacek(3), Halkjaer, Tine, Cullberg, Karina B, Underwood, Christina R, Schwartz, Thue W
- Database ID:
- RPEP-01491
Evidence Hierarchy
Frequently Asked Questions
What was studied?
Ghrelin, Small Molecule Agonists, and Modulators All Share the Same Receptor Binding Site
What was found?
The endogenous ghrelin, synthetic agonists, and ago-allosteric modulators all bind overlapping sites on the ghrelin receptor — they compete for the same binding pocket rather than using separate allosteric sites.
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Cite This Study
https://rethinkpeptides.com/research/RPEP-01491APA
Holst, Birgitte; Frimurer, Thomas M; Mokrosinski, Jacek; Halkjaer, Tine; Cullberg, Karina B; Underwood, Christina R; Schwartz, Thue W. (2009). Overlapping binding site for the endogenous agonist, small-molecule agonists, and ago-allosteric modulators on the ghrelin receptor.. Molecular pharmacology, 75(1), 44-59. https://doi.org/10.1124/mol.108.049189
MLA
Holst, Birgitte, et al. "Overlapping binding site for the endogenous agonist, small-molecule agonists, and ago-allosteric modulators on the ghrelin receptor.." Molecular pharmacology, 2009. https://doi.org/10.1124/mol.108.049189
RethinkPeptides
RethinkPeptides Research Database. "Overlapping binding site for the endogenous agonist, small-m..." RPEP-01491. Retrieved from https://rethinkpeptides.com/research/holst-2009-overlapping-binding-site-for
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.