The Endogenous Opioid System and Clinical Pain Management: A Practical Guide
This review connects endogenous opioid peptide biology to clinical pain management, showing how endorphins, enkephalins, and dynorphins modulate pain perception and how understanding this system improves opioid prescribing and non-pharmacological pain approaches.
Quick Facts
What This Study Found
The endogenous opioid system (endorphins, enkephalins, dynorphins) provides the biological foundation for clinical pain management: understanding endogenous analgesia mechanisms improves opioid drug selection, dosing, and integration with non-pharmacological approaches.
Key Numbers
How They Did This
review study on opioid-peptides, pain.
Why This Research Matters
Relevant for opioid-peptides, pain, receptor-signaling.
The Bigger Picture
Advances peptide research with clinical implications.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding The endogenous opioid system (endorphins, enkephalins, dynorphins) provides the biological foundation for clinical pain management: understanding endo
- Evidence Grade:
- moderate evidence.
- Study Age:
- Published in 2005.
- Original Title:
- The endogenous opioid system and clinical pain management.
- Published In:
- AACN clinical issues, 16(3), 291-301 (2005)
- Authors:
- Holden, Janean E, Jeong, Younhee, Forrest, Jeannine M
- Database ID:
- RPEP-01046
Evidence Hierarchy
Summarizes existing research on a topic.
What do these levels mean? →Frequently Asked Questions
What was studied?
The Endogenous Opioid System and Clinical Pain Management: A Practical Guide
What was found?
This review connects endogenous opioid peptide biology to clinical pain management, showing how endorphins, enkephalins, and dynorphins modulate pain perception and how understanding this system improves opioid prescribing and non-pharmacological pain approaches.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-01046APA
Holden, Janean E; Jeong, Younhee; Forrest, Jeannine M. (2005). The endogenous opioid system and clinical pain management.. AACN clinical issues, 16(3), 291-301.
MLA
Holden, Janean E, et al. "The endogenous opioid system and clinical pain management.." AACN clinical issues, 2005.
RethinkPeptides
RethinkPeptides Research Database. "The endogenous opioid system and clinical pain management." RPEP-01046. Retrieved from https://rethinkpeptides.com/research/holden-2005-the-endogenous-opioid-system
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.