How CCK Activates GLP-1 Brain Neurons: Through Noradrenergic and Glutamate Signaling
CCK stimulated hypothalamic GLP-1 neurons through alpha-1 adrenoceptor-mediated glutamatergic synaptic input, revealing how two gut satiety signals converge in the brain for integrated appetite control.
Quick Facts
What This Study Found
CCK stimulated hypothalamic GLP-1 neurons through alpha-1 adrenoceptor-mediated glutamatergic synaptic input, revealing how two gut satiety signals converge in the brain for integrated appetite control.
Key Numbers
How They Did This
research study.
Why This Research Matters
Relevant for peptide research.
The Bigger Picture
Advances peptide research.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
Trust & Context
- Key Stat:
- Key finding CCK stimulated hypothalamic GLP-1 neurons through alpha-1 adrenoceptor-mediated glutamatergic synaptic input, revealing how two gut satiety signals co
- Evidence Grade:
- emerging evidence.
- Study Age:
- Published in 2011.
- Original Title:
- CCK stimulation of GLP-1 neurons involves α1-adrenoceptor-mediated increase in glutamatergic synaptic inputs.
- Published In:
- Diabetes, 60(11), 2701-9 (2011)
- Authors:
- Hisadome, Kazunari, Reimann, Frank(3), Gribble, Fiona M(3), Trapp, Stefan
- Database ID:
- RPEP-01779
Evidence Hierarchy
Frequently Asked Questions
What was studied?
How CCK Activates GLP-1 Brain Neurons: Through Noradrenergic and Glutamate Signaling
What was found?
CCK stimulated hypothalamic GLP-1 neurons through alpha-1 adrenoceptor-mediated glutamatergic synaptic input, revealing how two gut satiety signals converge in the brain for integrated appetite control.
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Cite This Study
https://rethinkpeptides.com/research/RPEP-01779APA
Hisadome, Kazunari; Reimann, Frank; Gribble, Fiona M; Trapp, Stefan. (2011). CCK stimulation of GLP-1 neurons involves α1-adrenoceptor-mediated increase in glutamatergic synaptic inputs.. Diabetes, 60(11), 2701-9. https://doi.org/10.2337/db11-0489
MLA
Hisadome, Kazunari, et al. "CCK stimulation of GLP-1 neurons involves α1-adrenoceptor-mediated increase in glutamatergic synaptic inputs.." Diabetes, 2011. https://doi.org/10.2337/db11-0489
RethinkPeptides
RethinkPeptides Research Database. "CCK stimulation of GLP-1 neurons involves α1-adrenoceptor-me..." RPEP-01779. Retrieved from https://rethinkpeptides.com/research/hisadome-2011-cck-stimulation-of-glp1
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.