Ghrelin differentially affected hepatic and peripheral insulin sensitivity in mice — reducing liver insulin sensitivity while having different effects on peripheral tissues — revealing tissue-specific ghrelin-diabetes interactions.
Key findingGhrelin reduced hepatic insulin sensitivity (increased gluconeogenesis) while showing different effects on peripheral insulin sensitivity in mice, dem
What the researchers found
Ghrelin reduced hepatic insulin sensitivity (increased gluconeogenesis) while showing different effects on peripheral insulin sensitivity in mice, demonstrating tissue-specific ghrelin-insulin interactions with implications for diabetes pathophysiology.
Why it matters
Relevant for ghrp, diabetes.
How the study worked
animal-study study on ghrp, diabetes.
What this study cannot tell us
See abstract.
How to read the evidence
moderate evidence.
When this study was published
Published in 2006.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Ghrelin differentially affects hepatic and peripheral insulin sensitivity in mice.
Diabetologia, 49(4), 732-8
Citation
Heijboer, A C; van den Hoek, A M; Parlevliet, E T; Havekes, L M; Romijn, J A; Pijl, H; Corssmit, E P M. (2006). Ghrelin differentially affects hepatic and peripheral insulin sensitivity in mice.. Diabetologia, 49(4), 732-8.