Ghrelin Affects Insulin Sensitivity Differently in the Liver vs Muscles
Ghrelin differentially affected hepatic and peripheral insulin sensitivity in mice — reducing liver insulin sensitivity while having different effects on peripheral tissues — revealing tissue-specific ghrelin-diabetes interactions.
Quick Facts
What This Study Found
Ghrelin reduced hepatic insulin sensitivity (increased gluconeogenesis) while showing different effects on peripheral insulin sensitivity in mice, demonstrating tissue-specific ghrelin-insulin interactions with implications for diabetes pathophysiology.
Key Numbers
How They Did This
animal-study study on ghrp, diabetes.
Why This Research Matters
Relevant for ghrp, diabetes.
The Bigger Picture
Advances peptide research.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding Ghrelin reduced hepatic insulin sensitivity (increased gluconeogenesis) while showing different effects on peripheral insulin sensitivity in mice, dem
- Evidence Grade:
- moderate evidence.
- Study Age:
- Published in 2006.
- Original Title:
- Ghrelin differentially affects hepatic and peripheral insulin sensitivity in mice.
- Published In:
- Diabetologia, 49(4), 732-8 (2006)
- Authors:
- Heijboer, A C(2), van den Hoek, A M(2), Parlevliet, E T, Havekes, L M, Romijn, J A, Pijl, H, Corssmit, E P M
- Database ID:
- RPEP-01146
Evidence Hierarchy
Tests effects in animals (usually mice or rats), not humans.
What do these levels mean? →Frequently Asked Questions
What was studied?
Ghrelin Affects Insulin Sensitivity Differently in the Liver vs Muscles
What was found?
Ghrelin differentially affected hepatic and peripheral insulin sensitivity in mice — reducing liver insulin sensitivity while having different effects on peripheral tissues — revealing tissue-specific ghrelin-diabetes interactions.
Read More on RethinkPeptides
Cite This Study
https://rethinkpeptides.com/research/RPEP-01146APA
Heijboer, A C; van den Hoek, A M; Parlevliet, E T; Havekes, L M; Romijn, J A; Pijl, H; Corssmit, E P M. (2006). Ghrelin differentially affects hepatic and peripheral insulin sensitivity in mice.. Diabetologia, 49(4), 732-8.
MLA
Heijboer, A C, et al. "Ghrelin differentially affects hepatic and peripheral insulin sensitivity in mice.." Diabetologia, 2006.
RethinkPeptides
RethinkPeptides Research Database. "Ghrelin differentially affects hepatic and peripheral insuli..." RPEP-01146. Retrieved from https://rethinkpeptides.com/research/heijboer-2006-ghrelin-differentially-affects-hepatic
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.