Chronic ethanol produced opioid antinociceptive tolerance by inhibiting mu-opioid receptor endocytosis/recycling, explaining why chronic drinkers have altered pain sensitivity and opioid drug responses.
Key findingChronic ethanol produced opioid antinociceptive tolerance by inhibiting mu-opioid receptor endocytosis/recycling, explaining why chronic drinkers have
What the researchers found
Chronic ethanol produced opioid antinociceptive tolerance by inhibiting mu-opioid receptor endocytosis/recycling, explaining why chronic drinkers have altered pain sensitivity and opioid drug responses.
Why it matters
Relevant for peptide research.
How the study worked
research study.
What this study cannot tell us
See abstract.
How to read the evidence
emerging evidence.
When this study was published
Published in 2011.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
Common questions
What was studied?
What was found?
Read the original research
Chronic ethanol consumption in rats produces opioid antinociceptive tolerance through inhibition of mu opioid receptor endocytosis.
PloS one, 6(5), e19372
Citation
He, Li; Whistler, Jennifer L. (2011). Chronic ethanol consumption in rats produces opioid antinociceptive tolerance through inhibition of mu opioid receptor endocytosis.. PloS one, 6(5), e19372. https://doi.org/10.1371/journal.pone.0019372