Endogenous opioid peptides differentially regulated sucrose consumption versus food-reinforced behavior in mice, with kappa-opioid (dynorphin) and mu-opioid (endorphin/enkephalin) systems mediating different aspects of food reward.
Key findingKappa-opioid (dynorphin) and mu-opioid (endorphin/enkephalin) systems differentially regulated sucrose preference versus food-reinforced operant behav
What the researchers found
Kappa-opioid (dynorphin) and mu-opioid (endorphin/enkephalin) systems differentially regulated sucrose preference versus food-reinforced operant behavior in mice — different opioid families mediate different components of food reward and palatable eating.
Why it matters
Relevant for opioid-peptides, addiction.
How the study worked
animal-study study on opioid-peptides, addiction.
What this study cannot tell us
See abstract.
How to read the evidence
moderate evidence.
When this study was published
Published in 2006.
The bigger picture
Advances peptide research.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Differential involvement of endogenous opioids in sucrose consumption and food reinforcement.
Pharmacology, biochemistry, and behavior, 85(3), 601-11
Citation
Hayward, Michael D; Schaich-Borg, Alexandra; Pintar, John E; Low, Malcolm J. (2006). Differential involvement of endogenous opioids in sucrose consumption and food reinforcement.. Pharmacology, biochemistry, and behavior, 85(3), 601-11.