Inhibition of FOXP3 by stapled alpha-helical peptides dampens regulatory T cell function.
Quick Facts
What This Study Found
Lead SAH-FOXP3 peptides impeded Treg cell function and altered gene expression in vivo.
Key Numbers
How They Did This
The study involved designing and synthesizing stapled peptides to block FOXP3 interactions, followed by biochemical evaluations and in vivo testing.
Why This Research Matters
This research could pave the way for new therapies that enhance immune responses in conditions like cancer, where Treg cells inhibit effective treatment.
What This Study Doesn't Tell Us
The study primarily focuses on peptide design and in vitro/in vivo models, which may not fully translate to human applications.
Trust & Context
- Original Title:
- Inhibition of FOXP3 by stapled alpha-helical peptides dampens regulatory T cell function.
- Published In:
- Proceedings of the National Academy of Sciences of the United States of America, 119(42), e2209044119 (2022)
- Authors:
- Hawley, Katrina M, Eclov, Rachel J, Schnorenberg, Mathew R, Tian, Yu, Shah, Rhea N, Thomas-Toth, Anika T, Fefferman, Marie, Bird, Gregory H, Walensky, Loren D, Tirrell, Matthew V, LaBelle, James L
- Database ID:
- RPEP-06173
Evidence Hierarchy
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Cite This Study
https://rethinkpeptides.com/research/RPEP-06173APA
Hawley, Katrina M; Eclov, Rachel J; Schnorenberg, Mathew R; Tian, Yu; Shah, Rhea N; Thomas-Toth, Anika T; Fefferman, Marie; Bird, Gregory H; Walensky, Loren D; Tirrell, Matthew V; LaBelle, James L. (2022). Inhibition of FOXP3 by stapled alpha-helical peptides dampens regulatory T cell function.. Proceedings of the National Academy of Sciences of the United States of America, 119(42), e2209044119. https://doi.org/10.1073/pnas.2209044119
MLA
Hawley, Katrina M, et al. "Inhibition of FOXP3 by stapled alpha-helical peptides dampens regulatory T cell function.." Proceedings of the National Academy of Sciences of the United States of America, 2022. https://doi.org/10.1073/pnas.2209044119
RethinkPeptides
RethinkPeptides Research Database. "Inhibition of FOXP3 by stapled alpha-helical peptides dampen..." RPEP-06173. Retrieved from https://rethinkpeptides.com/research/hawley-2022-inhibition-of-foxp3-by
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.