This record provides bibliographic details and links to the original research. An editorial study breakdown is not available.
What the researchers found
Substance P requires specific interactions with NK1R to activate Gs signaling, while SP6-11 leads to Gq signaling.
Why it matters
Understanding how different peptides interact with receptors can lead to more effective pain management strategies. This research may inform the development of drugs that selectively target specific signaling pathways.
How the study worked
The study utilized cryogenic-electron microscopy and molecular dynamics simulations to analyze NK1R structures and interactions with peptides.
What this study cannot tell us
The study primarily focuses on receptor dynamics in vitro, which may not fully replicate in vivo conditions.
Read the original research
Selective G protein signaling driven by substance P-neurokinin receptor dynamics.
Nature chemical biology, 18(1), 109-115
Citation
Harris, Julian A; Faust, Bryan; Gondin, Arisbel B; Dämgen, Marc André; Suomivuori, Carl-Mikael; Veldhuis, Nicholas A; Cheng, Yifan; Dror, Ron O; Thal, David M; Manglik, Aashish. (2022). Selective G protein signaling driven by substance P-neurokinin receptor dynamics.. Nature chemical biology, 18(1), 109-115. https://doi.org/10.1038/s41589-021-00890-8