Selective G protein signaling driven by substance P-neurokinin receptor dynamics.
Quick Facts
What This Study Found
Substance P requires specific interactions with NK1R to activate Gs signaling, while SP6-11 leads to Gq signaling.
Key Numbers
How They Did This
The study utilized cryogenic-electron microscopy and molecular dynamics simulations to analyze NK1R structures and interactions with peptides.
Why This Research Matters
Understanding how different peptides interact with receptors can lead to more effective pain management strategies. This research may inform the development of drugs that selectively target specific signaling pathways.
What This Study Doesn't Tell Us
The study primarily focuses on receptor dynamics in vitro, which may not fully replicate in vivo conditions.
Trust & Context
- Original Title:
- Selective G protein signaling driven by substance P-neurokinin receptor dynamics.
- Published In:
- Nature chemical biology, 18(1), 109-115 (2022)
- Authors:
- Harris, Julian A, Faust, Bryan, Gondin, Arisbel B, Dämgen, Marc André, Suomivuori, Carl-Mikael, Veldhuis, Nicholas A, Cheng, Yifan, Dror, Ron O, Thal, David M, Manglik, Aashish
- Database ID:
- RPEP-06171
Evidence Hierarchy
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Cite This Study
https://rethinkpeptides.com/research/RPEP-06171APA
Harris, Julian A; Faust, Bryan; Gondin, Arisbel B; Dämgen, Marc André; Suomivuori, Carl-Mikael; Veldhuis, Nicholas A; Cheng, Yifan; Dror, Ron O; Thal, David M; Manglik, Aashish. (2022). Selective G protein signaling driven by substance P-neurokinin receptor dynamics.. Nature chemical biology, 18(1), 109-115. https://doi.org/10.1038/s41589-021-00890-8
MLA
Harris, Julian A, et al. "Selective G protein signaling driven by substance P-neurokinin receptor dynamics.." Nature chemical biology, 2022. https://doi.org/10.1038/s41589-021-00890-8
RethinkPeptides
RethinkPeptides Research Database. "Selective G protein signaling driven by substance P-neurokin..." RPEP-06171. Retrieved from https://rethinkpeptides.com/research/harris-2022-selective-g-protein-signaling
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.