PYY3-36 Causes Taste Aversion at Appetite-Suppressing Doses — A Nausea Concern
PYY3-36 at doses that suppress appetite also produced conditioned taste aversion in mice, suggesting its anorectic effect may partly involve nausea/malaise rather than pure physiological satiety — a caution for obesity drug development.
Quick Facts
What This Study Found
Peripheral PYY3-36 at appetite-suppressing doses produced conditioned taste aversion (learned food avoidance suggesting nausea), indicating its anorectic effect may partly involve malaise rather than pure satiety — an important consideration for PYY-based obesity drugs.
Key Numbers
How They Did This
animal-study study on neuropeptides, weight-loss.
Why This Research Matters
Relevant for neuropeptides, weight-loss, receptor-signaling.
The Bigger Picture
Advances peptide research with clinical implications.
What This Study Doesn't Tell Us
See abstract.
Questions This Raises
- ?Further research needed.
- ?Clinical translation to evaluate.
Trust & Context
- Key Stat:
- Key finding Peripheral PYY3-36 at appetite-suppressing doses produced conditioned taste aversion (learned food avoidance suggesting nausea), indicating its anorec
- Evidence Grade:
- moderate evidence.
- Study Age:
- Published in 2005.
- Original Title:
- Peripheral administration of PYY(3-36) produces conditioned taste aversion in mice.
- Published In:
- Cell metabolism, 1(3), 159-68 (2005)
- Authors:
- Halatchev, Ilia G(3), Cone, Roger D(3)
- Database ID:
- RPEP-01042
Evidence Hierarchy
Tests effects in animals (usually mice or rats), not humans.
What do these levels mean? →Frequently Asked Questions
What was studied?
PYY3-36 Causes Taste Aversion at Appetite-Suppressing Doses — A Nausea Concern
What was found?
PYY3-36 at doses that suppress appetite also produced conditioned taste aversion in mice, suggesting its anorectic effect may partly involve nausea/malaise rather than pure physiological satiety — a caution for obesity drug development.
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Cite This Study
https://rethinkpeptides.com/research/RPEP-01042APA
Halatchev, Ilia G; Cone, Roger D. (2005). Peripheral administration of PYY(3-36) produces conditioned taste aversion in mice.. Cell metabolism, 1(3), 159-68.
MLA
Halatchev, Ilia G, et al. "Peripheral administration of PYY(3-36) produces conditioned taste aversion in mice.." Cell metabolism, 2005.
RethinkPeptides
RethinkPeptides Research Database. "Peripheral administration of PYY(3-36) produces conditioned ..." RPEP-01042. Retrieved from https://rethinkpeptides.com/research/halatchev-2005-peripheral-administration-of-pyy336
Access the Original Study
Study data sourced from PubMed, a service of the U.S. National Library of Medicine, National Institutes of Health.
This study breakdown was produced by the RethinkPeptides research team. We analyze and report published research findings without making health recommendations. All interpretations are based solely on the published abstract and study data.