PYY3-36 at doses that suppress appetite also produced conditioned taste aversion in mice, suggesting its anorectic effect may partly involve nausea/malaise rather than pure physiological satiety — a caution for obesity drug development.
Key findingPeripheral PYY3-36 at appetite-suppressing doses produced conditioned taste aversion (learned food avoidance suggesting nausea), indicating its anorec
What the researchers found
Peripheral PYY3-36 at appetite-suppressing doses produced conditioned taste aversion (learned food avoidance suggesting nausea), indicating its anorectic effect may partly involve malaise rather than pure satiety — an important consideration for PYY-based obesity drugs.
Why it matters
Relevant for neuropeptides, weight-loss, receptor-signaling.
How the study worked
animal-study study on neuropeptides, weight-loss.
What this study cannot tell us
See abstract.
How to read the evidence
moderate evidence.
When this study was published
Published in 2005.
The bigger picture
Advances peptide research with clinical implications.
Questions still open
- Further research needed.
- Clinical translation to evaluate.
Common questions
What was studied?
What was found?
Read the original research
Peripheral administration of PYY(3-36) produces conditioned taste aversion in mice.
Cell metabolism, 1(3), 159-68
Citation
Halatchev, Ilia G; Cone, Roger D. (2005). Peripheral administration of PYY(3-36) produces conditioned taste aversion in mice.. Cell metabolism, 1(3), 159-68.